β2 GPⅠ及其抗体与抗磷脂综合征的研究进展  

Research Progress of β2 GlycoproteinⅠ and Anti-β2GPⅠ Antibodies and Antiphospholipid Syndrome

作　　者：孙娜[1] 张文静[1] 高飞[1] 刘彦虹[1] 

机构地区：[1]哈尔滨医科大学附属第二医院检验科,哈尔滨150086

出　　处：《现代检验医学杂志》2015年第1期19-22,共4页Journal of Modern Laboratory Medicine

基　　金：国家自然科学基金（编号：81270394）.

摘　　要：抗磷脂综合征（APS）是一种以血栓形成和（或）习惯性流产为临床特征的自身免疫性疾病。β2糖蛋白Ⅰ（β2 GPⅠ）是该病的主要抗原，抗β2 GPⅠ抗体是以β2 GPⅠ为靶抗原的自身抗体。研究表明，β2 GPⅠ及其自身抗体在 APS血栓形成的致病过程中起到重要作用。目前 APS的诊断与治疗也越来越受到人们的重视，检测抗β2 GPⅠDⅠ抗体能特异性诊断APS，分子水平的研究也成为治疗 APS的新方向。该文就β2 GPⅠ、抗β2 GPⅠ抗体与 APS的相关性进展作以综述。Antiphospholipid syndrome （APS）is an autoimmune multisystem disorder characterized clinically by recurrent thrombosis and pregnancy morbidity.β2-glycoproteinⅠ （β2GPⅠ）is the major antigen in the APS.Anti-β2GPⅠ antibody is the autoantibody which targets toβ2GPⅠ.There is overwhelming evidence thatβ2GPⅠand anti-β2GPⅠ antibody play an important role in the pathogenesis of APS.Now the diagnosis and treatment of anti-β2GPⅠ antibody are more and more get people＆#39;s attention,detection of anti-β2GPⅠDⅠ antibody can specifically diagnose APS and research of the molecular level may provide a new therapeutic target for APS.In this paper,β2GPⅠ,anti-β2GPⅠ antibody and APS associated development were reviewed.

关 键 词：β2糖蛋白Ⅰ 抗β2GP Ⅰ抗体 抗磷脂综合征 

分 类 号：R392.11[医药卫生—免疫学]