肺炎衣原体感染与急性脑梗死的相关性研究  

Correlation between Chlamydia pneumoniae infection and acute cerebral infarction

作　　者：刘红[1] 郭娜 薛新红[1] 赵敏[1] 郭栋[1] 曲怀谦[1] 

机构地区：[1]泰山医学院附属聊城市人民医院神经内科,山东聊城252000 [2]聊城市中医医院脑病科,山东聊城252000

出　　处：《中华医院感染学杂志》2015年第6期1257-1259,共3页Chinese Journal of Nosocomiology

基　　金："十一五"国家科技支撑计划基金资助项目(2006BA101A11)

摘　　要：目的研究肺炎衣原体(CP)感染对血脂水平、C-反应蛋白(CRP)及血液流变学指标影响,以探讨肺炎衣原体感染与急性脑梗死的相关性。方法随机选择2013年1月-2014年1月医院收治的65例急性脑梗死患者作为研究组,选择与研究组匹配的同期于医院进行体检的健康志愿者65名作为对照组,采用微量免疫荧光法(MIF)检测两组受试人员血清肺炎衣原体特异性IgA、IgM、IgG,并检测比较两组低密度脂蛋白(LDL)、高脂血症(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、CPR及血液流变学指标。结果研究组IgA、IgG抗体阳性率分别为81.54%、88.62%,慢性感染率为73.85%,对照组IgA、IgG抗体阳性率分别为41.54%、61.54%,慢性感染率12.31%,研究组以上各项指标均显著高于对照组,而两组IgM阳性率和急性感染率差异无统计学意义;研究组TC、LDL、TG及CRP水平均显著高于对照组,HDL水平则显著低于对照组,研究组感染患者血脂及CPR水平与未感染患者差异有统计学意义(P<0.05);研究组感染患者全血黏度、血细胞比容、血浆黏度及红细胞聚集指数较之对照组及研究组未感染患者均显著增高,差异有统计学意义(P<0.05);IgA、IgG抗体阳性为急性脑梗死独立危险因素,IgM抗体阳性与之无相关性。结论肺炎衣原体慢性感染与急性脑梗死相关,肺炎衣原体通过导致炎症损伤、血脂代谢异常并影响血液动力学参与急性脑梗死的病变过程。OBJECTIVE To study the influence of Chlamydia pneumoniae （CP） infection on the levels of blood lip-ids and C-reactive protein （CRP） as well as hemorheological parameters so as to explore the relationship between the CP infection and the acute cerebral infarction .METHODS Totally 65 patients with acute cerebral infarction who were treated from Jan 2013 to Jan 2014 were randomly assigned as the study group ,meanwhile 65 healthy volun-teers who received physical examination were chosen as the study group .The levels of the serum CP specific IgA , IgM ,and IgG of the two groups of participants were determined by using micro-immunofluorescence assay ,and the levels of the low-density lipoprotein （LDL ） ,hyperlipidemia ,total cholesterol （TC） ,high-density lipoprotein （HDL） ,and CRP as well as the hemorheological parameters were detected and compared between the two groups . RESULTS The positive rate of IgA antibody was 81 .54% in the study group ,41 .54% in the control group ;the positive rate of IgG antibody was 88 .62% in the study group ,61 .54% in the control group ;the incidence of chro-nic infections was 73 .85% in the study group ,12 .31% in the control group ;the levels of the above indicators of the study group were significantly higher than those of the control group ,however ,there was no statistically sig-nificant difference in the positive rate of IgM or the incidence of acute infections between the two groups .The lev-els of the TC ,LDL ,heperlipidemia ,and CRP of the study group were significantly higher than those of the con-trol group ;however ,the level of HDL of the study group was significantly lower than that of the control group , there was significant difference in the blood lipid or CRP between the patients with infections and the patients without infections in the study group （P〈 0 .05） .The whole blood viscosity ,hematocrit ,plasma viscosity ,and e-rythrocyte aggregation index of the patients with infections in the study group were significantly higher than those of

关 键 词：肺炎衣原体 急性脑梗死 感染 危险因素 相关性研究 

分 类 号：R374[医药卫生—病原生物学]