病毒性肺炎患儿的病原学及细胞免疫功能分析研究  

Study on etiology and cellular immune function of children with viral pneumonia

作　　者：李素芳[1] 袁永红[1] 田军[1] 

机构地区：[1]杭州市萧山区第一人民医院儿科,浙江杭州311200

出　　处：《中华医院感染学杂志》2015年第6期1278-1280,共3页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生基金资助项目(2013KYA043)

摘　　要：目的分析病毒性肺炎患儿的病原学特点和免疫功能,比较重症和轻症肺炎患儿之间的病原学特点和免疫功能差异,为临床患儿病毒性肺炎的治疗提供参考价值。方法选取2010年1月-2012年6月68例病毒性肺炎患儿作为研究组,包括轻症肺炎43例、重症肺炎25例,另选取30名健康儿童作为对照组,比较研究组和对照组之间的病毒分布特征和细胞免疫指标差异。结果 68例患儿中单一感染51例占75.00%,混合感染17例占25.00%;以感染呼吸道合胞病毒(RSV)和流感病毒(IFV)比例最高,分别占20.59%和17.65%;混合感染中以IFV+副流感病毒(PIV)最高,占10.29%;研究组轻症肺炎与重症肺炎患儿病毒感染比较,差异有统计学意义(P<0.05);研究组轻症肺炎及重症肺炎与对照组患儿CD3+、CD4+、CD8+和CD4+/CD8+比较差异均有统计学意义(P<0.05)。结论患儿病毒性肺炎病原体感染复杂、免疫功能紊乱,尤其是重症肺炎患儿混合感染较为常见,免疫功能更差,应及早进行病原学检测和免疫功能检查,制定最佳治疗方案。OBJECTIVE To observe the etiological characteristics and immune function of the children with viral pneumonia and compare the etiological characteristics and immune function between the children with severe pneu-monia and the children with mild pneumonia so as to provide guidance for clinical treatment of the children with vi -ral pneumonia .METHODS A total of 68 children with viral pneumonia who were treated from Jan 2010 to Jun 2012 were assigned as the study group ,including 43 cases of mild pneumonia and 25 cases of severe pneumonia ;while 30 healthy children were chosen as the control group .The distribution of the viruses and the cellular immune indi-cators were observed and compared between the two groups .RESULTS Of the 68 children ,51 had the single infec-tion ,accounting for 75 .00% ,and 17 had the mixed infection ,accounting for 25 .00% .The children infected with respiratory syncytial virus （RSV） accounted for 20 .59% ,and the children infected with influenza virus （IFV） ac-counted for 17 .65% .Among the children with mixed infection ,the children with mixed infection of IFV plus parainfluenza virus （PIV） accounted for 10 .29% .There was significant difference in the incidence of viral infec-tion between the children with mild pneumonia and the children with severe pneumonia in the study group （P 〈0 .05） .There was significant difference in the CD3 ＋ ,CD4 ＋ ,CD8 ＋ ,or CD4 ＋ /CD8 ＋ between the children with mild pneumonia and the children with severe pneumonia in the study group and the control group （ P 〈 0 .05） . CONCLUSION The pathogens causing viral pneumonia in the children are complex and may result in the disorder of immune function ,and the mixed infection is prevalent among the children with severe pneumonia ,with the im-mune function even worse .It is necessary to perform the etiological detection and the immune function examination in a timely manner and propose the optimal treatment program .

关 键 词：患儿 病毒性肺炎 免疫功能 重症肺炎 

分 类 号：R378[医药卫生—病原生物学]