胎盘多肽注射液对开放性骨折患者骨愈合时间及感染发生率的影响  

Influence of placental peptide injection on bone healing time and incidence of infections in open fracture patients

作　　者：滕家松[1] 常树松[1] 魏雪飞[1] 

机构地区：[1]大庆油田总医院骨科,黑龙江大庆163000

出　　处：《中华医院感染学杂志》2015年第6期1349-1350,1353,共3页Chinese Journal of Nosocomiology

基　　金：黑龙江省自然科学基金资助项目(D201023)

摘　　要：目的探究胎盘多肽注射液对四肢开放性骨折患者骨愈合时间及感染发生率的影响,为患者预后提供保障。方法从2010年3月-2012年6月就诊的四肢开放性骨折患者中随机抽出100例平均分为两组,每组各50例,对照组患者进行常规手术治疗,试验组患者在进行相同的常规治疗的基础上加入胎盘多肽注射液治疗,比较两组患者在治疗后的骨折愈合所需时间以及不同疗法引起的感染情况。结果经过治疗,试验组患者肱骨愈合时间为(14.2±1.5)周、尺桡骨愈合时间为(14.0±1.2)周、股骨愈合时间为(13.5±0.9)周、胫腓骨愈合时间为(13.4±1.4)周,对照组患者愈合时间分别为(17.9±1.8)、(18.3±1.9)、(17.1±2.1)、(17.2±2.9)周,感染率试验组患者2.0%、对照组患者28.0%,所有数据的比较差异均有统计学意义(P<0.05)。结论胎盘多肽注射液在对于四肢开放性骨折患者的治疗,不仅可以提高患者骨折愈合的速度,还可以有效的减少患者术后出现的感染情况,具有显著的疗效。OBJECTIVE To explore the influence of placental peptide injection on bone healing time and incidence of infections in limbs open fracture patients so as to ensure the prognosis .METHODS A total of 100 limbs open frac-ture patients who were treated in the hospital from Mar 2010 to Jun 2012 were randomly assigned and divided into two groups ,with 50 cases in each ;the patients in the control group received the conventional surgery ,while the patients in the experimental group were treated with additional placental peptide injection based on the conventional therapy ;the bone healing time and the incidence of infections were observed and compared between the two groups .RESULTS After the treatment ,the healing time of humerus fracture was （14 .2 ± 1 .5） weeks in the experi-mental group ,（17 .9 ± 1 .8）weeks in the control group ;the healing time of radius and ulna fracture was （14 .0 ± 1 .2）weeks in the experimental group ,（18 .3 ± 1 .9）weeks in the control group ;the healing time of femur frac-ture was （13 .5 ± 0 .9）weeks in the experimental group ,（17 .1 ± 2 .1） weeks in the control group ;the healing time of tibiofibula fracture was （13 .4 ± 1 .4）weeks in the experimental group ,（17 .2 ± 2 .9）weeks in the control group ;the incidence of infections was 2 .0% in the experimental group ,28 .0% in the control group ;as compared with all the data ,there was significant difference （P 〈 0 .05） .CONCLUSION As for the treatment of the patients with limbs fracture ,the placental peptide injection can not only promote the the bone healing but effectively reduce the incidence of postoperative infections .

关 键 词：胎盘多肽注射液 开放性骨折 愈合时间 感染 

分 类 号：R181.32[医药卫生—流行病学]