妥曲珠利纳米乳在鸡体内药代动力学研究  

Study on Pharmacokinetics of Toltrazuril Nanoemulsion in Chickens

作　　者：张志美[1,2] 郭时金[1,2] 付石军 王建军[1,2] 徐倩倩[1,2] 张颖[1,2] 王艳萍[1,2] 沈志强[1,2] 

机构地区：[1]山东省滨州畜牧兽医研究院,山东滨州256600 [2]山东绿都安特动物药业有限公司,山东滨州256600

出　　处：《动物医学进展》2015年第4期55-58,共4页Progress In Veterinary Medicine

基　　金：2012年山东省第二批技术创新项目(201220916001)

摘　　要：为了解妥曲珠利纳米乳在鸡体内的药物动力学过程,按7mg/kg经口灌服妥曲珠利纳米乳,高效液相色谱法测定血药浓度,通过3P87药物动力学程序软件分析药时数据,同时以妥曲珠利溶液为对照。结果表明,健康肉鸡单次灌服妥曲珠利纳米乳和妥曲珠利溶液后血药浓度-时间数据均符合有吸收二室模型,主要药代动力学参数分别为:T1/2α:11.202h±0.707h和4.203h±0.303h,T1/2β:46.689h±9.247h和23.774h±1.744h,AUC:368.958(μg·mL-1)h±37.36)/(μg·mL-1)h和175.249(μg·mL-1)h±14.256)/(μg·mL-1)h。提示妥曲珠利纳米乳在鸡体内具有明显的缓释性,同时生物利用度极显著提高。To study the pharmacokinetics of toltrazuril nanoemulsion in chickens for clinic use,the medicine was taken orally at the dose of 7mg/kg.The concentration of toltrazuril was determined by HPLC and the data were analyzed with the pharmacokinetic software 3P87.Toltrazuril solution was chosen as the contrast medicine.Results showed that the concentration-time course of toltrazuril in plasma fitted a 2-compartment open model.The main pharmacokinetic parameters were as follows：T1/2α11.202h±0.707 hand 4.203h±0.303 h,T1/2β46.689h±9.247 hand 23.774h±1.744 h,AUC 368.958（μg/mL）h±37.36（μg/mL）h and 175.249（μg/mL）h±14.256（μg/mL）h.It can be seen that toltrazuril nanoemulsion had a good quality of slow releasing and high bioavailability.

关 键 词：妥曲珠利纳米乳 鸡 药代动力学 

分 类 号：S859.795[农业科学—临床兽医学]