甘氨酸的免疫调节作用及其分子机制  

Immunomodulatory Effects of Glycine and Its Molecular Mechanism

作　　者：杜瑞平[1] 张兴夫[1] 高民[1] 敖长金[2] 

机构地区：[1]内蒙古农牧业科学院动物营养与饲料研究所,呼和浩特010031 [2]内蒙古农业大学动物科学学院,呼和浩特010018

出　　处：《动物营养学报》2015年第3期663-670,共8页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家"973"重点基础研究发展计划(2011CB100803);中科院"西部之光"人才培养项目

摘　　要：甘氨酸是一种传统氨基酸分类上的非必需氨基酸,参与了蛋白质和与许多重要的代谢有关的生理活性分子的合成,并且是中枢神经系统中的一种重要抑制性神经递质。近年来的研究发现,除了对缺血再灌注损伤、休克、移植、酒精性肝炎、肝纤维化、关节炎、肿瘤和药物毒性等具有生理保护作用外,甘氨酸还有抗炎和免疫调节作用,其准确机制尚没有完全阐明。本文从氨基酸与免疫的关系切入,综述了甘氨酸的基本特性、主要生理作用、抗炎和免疫调节作用及其可能的分子机制,讨论了甘氨酸调节泌乳反刍动物乳腺炎的可能性,旨在为甘氨酸作为天然免疫调节剂的实践应用提供理论指导。Glycine is a simple, non-essential amino acid, participates in the synthesis of protein and many physiologically important molecules, and it has been well characterized as an inhibitory neurotransmitter in the central nervous system. Except for the protection of glycine in experimental models of ischaemia-reperfusion in-jury, shock, transplantation, alcoholic hepatitis, hepatic fibrosis, arthritis, tumour and drug toxicity, ample evidence has been generated demonstrating that glycine has anti-inflammatory and immunomodulatory function, but the exact mechanism（ s） responsible for the protective and anti-inflammatory action of glycine are still un-clear. This paper reviewed the basic characteristics, the physiological protective fuctions, anti-inflammatory and immunomodulatory effects and possible molecular mechanisms of glycine, discussed the modulation possi-bility of glycine on mastitis control of lactating ruminants, and provided promising insights into the develop-ment of glycine as a natural immunomodulatory agent in practice.

关 键 词：甘氨酸 抗炎 甘氨酸受体 

分 类 号：S852.2[农业科学—基础兽医学]