骨松益骨方联合阿仑膦酸钠治疗脾肾气虚血瘀型原发性骨质疏松症的疗效观察  

Clinical Observation of Gusong Yigu Decoction combined with Alendronate Sodium Tablets on Primary Osteoporosis Accompanied with Qi Deficiency of Kidney-Spleen and Blood Stasis

作　　者：孔西建[1] 李盈盈[1] 翟远坤[1] 叶进[1] 吴丹[1] 毛春焕[1] 

机构地区：[1]河南省洛阳正骨医院,河南洛阳471002

出　　处：《中医药导报》2015年第6期19-24,共6页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金资助项目(81073037);国家自然科学基金资助项目(31071043);洛阳市应用技术研究与开发资金项目(1101057A)

摘　　要：目的:观察骨松益骨方联用阿仑膦酸钠治疗脾肾气虚血瘀型原发性骨质疏松症的疗效。方法:将186例脾肾气虚血瘀型原发性骨质疏松症患者随机分为3组,包括骨松益骨方组63例、阿仑膦酸钠组61例和联用组62例,治疗6个月后,观察3组治疗前后的骨密度、疼痛症状评分、骨代谢指标及脆性骨折发生率的改善情况。结果:治疗前后比较,3组均能有效防止骨密度下降;骨痛症状有不同程度的改善;骨吸收得到显著抑制;脆性骨折发生率也明显降低(P<0.05)。联用组与单用组相比,联用组的各项指标均优于骨松益骨方组和阿仑膦酸钠组(P<0.05)。结论:骨松益骨方和阿仑膦酸钠均可改善脾肾气虚血瘀型原发性骨质疏松症患者的疼痛症状,提高骨密度,降低骨转换,联用效果更佳。Objective： To observe the effects of Gusong Yigu decoction（骨松益骨方,GSYGD） combined with alendronate sodium tablets on the primary osteoporosis patients who possessed qi deficiency of kidney-spleen and blood stasis. Methods： The186 patients with primary osteoporosis were collected and divided into three groups, 63 patients in GSYGD group, 61 patients in alendronate sodium tablets group and 62 patients in combination group. Bone mineral density, pain score, blood calcium, blood phosphorus, bone metabolism markers and incidence rate of bone fragile fracture were investigated after the treatment of 6months. Results： Compared with pre-therapy, GSYGD and alendronate sodium tablets could prevent the decrease of bone mineral density, relieve the skeletal pain, inhibit bone resorption and decrease the incidence rate of bone fragile fracture（ P 0.05）, no matter combination or alone. However, all these markers in the combination group are better than the GSYGD and alendronate sodium tablets group（P0.05）. Conclusion： Gusong Yigu decoction and alendronate sodium tablets both could improve the clinial symptoms in primary osteoporosis patients with qi deficiency of kidney-spleen and blood stasis, but combination could get better results.

关 键 词：原发性骨质疏松症 脾肾气虚 血瘀 骨松益骨方 阿仑膦酸钠 骨密度 骨代谢指标 脆性骨折发生率 

分 类 号：R274[医药卫生—中医骨伤科学]