肝脏Resistin与DM非酒精性脂肪肝大鼠糖脂代谢的发生机制及中药干预的作用研究  

The Occurrence Mechanism of Glucose and Lipid Metabolism and Resistin and Effects of Tanggan Kang on Diabetic Rats with Fatty Liver

作　　者：彭伟[1] 钱秋海[1] 钱卫斌[2] 蔡欣蕊[3] 白海龙[4] 

机构地区：[1]山东中医药大学附属医院,山东济南250011 [2]日本鸟取大学医学部 [3]山东中医药大学第一临床医学院,山东济南250014 [4]沧州市中西医结合医院,河北沧州061013

出　　处：《中医药导报》2015年第6期29-31,35,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：山东省自然科学基金委面上项目(ZR2012HM093);山东省中医药科学技术研究项目(2011-038)

摘　　要：目的:探讨糖肝康对糖尿病脂肪肝模型大鼠肝组织抵抗素(Resistin)表达的影响机制。方法:采用链脲佐菌素联合高脂饮复制糖尿病脂肪肝大鼠模型,成模后随机分为模型组、护肝宁组和糖肝康小、中、大剂量组,每组10只,另取10只正常大鼠作为空白组,分别给予相应药物干预,12周后Western Blot方法检测大鼠肝组织Resistin的表达。结果:与空白组比较,模型组肝组织Resistin表达明显减少(P<0.01);与模型组比较,各给药组肝组织Resistin表达明显增加(P<0.01),糖肝康中、大剂量组优于护肝宁组(P<0.01)。结论:糖肝康可能通过增加Resistin表达水平,改善肝脏代谢进而保护肝脏。Objective： To observe the effect mechanism of Tanggankang on the expression of Resistin of diabetic rats with fatty liver. Methods： The model of fatty liver diabetic rats was established by injecting streptozotocin（STZ） and feeding with highfat diet. After successful modeling, the rats were randomly divided into six groups： model group, Huganning group, blank group,Tanggankang group of small dose, Tanggankang group of middle dose and Tanggankang group of large dose,10 each, and respec-tively received corresponding drug, then the content of Resistin in liver was observed with Western Blot after 12 weeks.Results：Compared with the blank group, the content of Resitin in model group decreased significantly（ P0.01）; compared with the model group, all the drug-received groups have more Resistin in liver（P0.01）, and Tanggankang group of middle dose and large dose was higher than that in Huganning group（P0.01）. Conclusion： Tanggankang could improve the liver metabolism and protect the liver by increasing the expression of Resistin.

关 键 词：糖肝康 糖尿病脂肪肝 RESISTIN 大鼠 

分 类 号：R285.5[医药卫生—中药学]