可逆性输卵管节育器干预大鼠子宫内膜异位症的实验研究  

Experimental Research about Reversible Oviduct Synthetic Therapy for Endometriosis in Rats

作　　者：王哲[1] 路芳[2] 陈佃红[2] 张平[1] 

机构地区：[1]山东中医药大学附属医院,济南250011 [2]山东中医药大学

出　　处：《国际妇产科学杂志》2015年第1期54-56,121,共4页Journal of International Obstetrics and Gynecology

基　　金：山东省中医药科学研究项目(2010-093)

摘　　要：目的:逆流法建立大鼠子宫内膜异位症(EMs)模型,观察可逆性输卵管节育器对大鼠EMs的预防作用。方法:30只大鼠随机分为3组,每组各10只,实验组逆流造模同时放置可逆性输卵管节育器,阴性对照组逆流造模,空白对照组不做处理。术后8周检测血清中抗子宫内膜抗体(Em Ab)和CA125,观察组织形态学变化。结果:实验8周后3组大鼠血Em Ab、CA125浓度差异有统计学意义(均P<0.05)。阴性对照组血Em Ab、CA125浓度高于空白对照组和实验组(均P<0.05)。空白对照组无1例发病,阴性对照组8例发病,异位病灶体积(74.20±6.32)mm3,实验组1例发病,异位病灶体积为1.50 mm3。结论:可逆性输卵管节育器可预防大鼠EMs的发生。Objective：To build the rat model of endometriosis by reflux method, observed the preventive effect of reversible oviduct synthetic on endometriosis in rats. Methods：The rats were divided into three groups randomly, experimental group（molding by reflux method and placement reversible oviduct synthetic）, negative control group（molding by reflux method）,blank control group（no processing）. Then tested Em Ab and CA125 in serum, and observed the tissue morphological variations in eight weeks after operation. Results：There were difference in Em Ab and CA125 in serum between three group（P〈0.05）, and the negative control group was significantly higher than the experimental group and blank control group（ P〈0.05）. There were also no obvious difference in histomorphology between the experimental group and the blank group. Neither of them developed endometriosis. In histomorphology observation, there is none in blank control group, 8 cases in negative control group, ectopic lesions volume（74.20±6.30）mm3, 1 case in experimental group, volume for the onset of ectopic lesions 1.50 mm3. Conclusions：The reversible oviduct synthetic could prevent endometriosis in rats.

关 键 词：子宫内膜异位症 避孕器械 输卵管 动物实验 大鼠 Wistar CA-125抗原 

分 类 号：R711.71[医药卫生—妇产科学]