足月新生儿高胆红素血症对甲状腺功能影响的临床研究  

The influence on thyroid function in full-term neonatal hyperbilirubinemia

作　　者：杨文[1,2] 陈彦香[2] 黄列[2] 陈少峰[2] 纪永佳[2] 胡晓磊[2] 

机构地区：[1]宁夏医科大学,宁夏银川750004 [2]宁夏银川市第一人民医院新生儿科,宁夏银川750001

出　　处：《宁夏医学杂志》2015年第3期232-234,共3页Ningxia Medical Journal

基　　金：宁夏银川市科技攻关项目(2012ZYS213)

摘　　要：目的观察不同程度高胆红素血症的足月新生儿甲状腺激素水平,探讨高胆红素血症对足月新生儿甲状腺功能的影响。方法选择新生儿高胆红素血症的患儿100例为观察组,分为3组(轻度30例,中度40例,重度30例)。选用产科正常分娩30例健康足月新生儿为对照组。采用电化学免疫分析法,进行血清甲状腺功能即T3、FT3、T4、FT4、TSH、TG测定。结果重度组T3、FT3、T4、FT4低于对照组,差异有统计学意义(P<0.05,TSH、TG与对照组比较差异无统计学意义(P>0.05);轻度、中度组T3、FT3低于对照组,差异有统计学意义(P<0.05),T4、FT4、TSH、TG与对照组比较差异无统计学意义(P>0.05)。重度组T3、FT3低于轻度、中度组,差异有统计学意义(P<0.05),T4、FT4、TSH、TG比较差异无统计学意义(P>0.05)。高胆患儿的血清T3、FT3水平与TBIL水平呈负相关性(P<0.05)。结论在患高胆红素血症的足月新生儿中,重度高胆红素血症可造成新生儿甲状腺功能损害,T3、FT3可作为甲状腺功能早期损害的检测指标,应对高胆患儿进行甲状腺功能检查。Objective To observe the full- term neonatal thyroid hormone levels in different levels of hyperbilirubinemia and to investigate how the full- term neonatal hyperbilirubinemia affects the thyroid function. Methods 100 hyperbilirubinemia patients were chosen as the observation group. The neonates were divided into three groups as the light degree,the moderate degree and the severe degree. 30 healthy full- term neonates in our obstetrical department were chose as the control group. Total triiodothyronine（ T3）,free T3（ FT3）,total thyroxine（ T4）,free T4（ FT4）,thyroid- stimulating hormone（ TSH）,thyroglobulin（ TG） were determined by Electrochemical Immunoassay in the neonates. Results The concentrations of T3,FT3,T4 and FT4 in the severe degree group were lower than in the control group（ P 〈 0. 05）. There was no statistical significance when comparing the concentrations of the TSH and TG in the severe degree group with the control group（ P 〉 0. 05）. The concentrations of T3 and FT3 in the light degree and the moderate degree group were lower than the control group（ P 〈 0. 05）. There was no statistical significance when comparing the concentrations of the T4,FT4,TSH and TG in the light degree and the moderate degree group with the control group（ P 〉 0. 05）. The concentrations of the T3 and FT3 in the severe group were lower than the light degree and the moderate degree group（ P 〈 0. 05）. There was no statistical significance when comparing the concentrations of the T4,FT4,TSH and TG in the severe degree group with the light degree and the moderate group（ P 〉 0. 05）. And there was negative correlation between the T3 and FT3 in the neonates with hyperbilirubinemia and the level of TBIL（ P 〈 0. 05）. Conclusion Suffered hyperbilirubinemia in full- term neonates,severe hyperbilirubinemia can cause neonatal thyroid dysfunction. T3 and FT3 can be used as sensitive indicators of thyroid function to detect early damage in full- term neonates. And these patients sh

关 键 词：足月新生儿 高胆红素血症 甲状腺功能 

分 类 号：R722.1[医药卫生—儿科]