PC-1基因K121Q多态性与2型糖尿病合并视网膜病变的相关性研究  

The correlation of the K121Q polymorphism of PC-1 gene and Diabetic retinopathy

作　　者：邹晓燕[1] 孙玉宁[2] 谢晓敏[1] 李仁达[1] 李玲[1] 刘惠莉[1] 史静[1] 侯庆宁[1] 牛旭东[1] 强丹[1] 

机构地区：[1]宁夏银川市第一人民医院内分泌科,宁夏银川750001 [2]宁夏医科大学基础学院生化教研室,宁夏银川750004

出　　处：《宁夏医学杂志》2015年第3期246-247,共2页Ningxia Medical Journal

基　　金：宁夏自然科学基金资助项目(NZ1285)

摘　　要：目的探讨浆细胞膜糖蛋白(PC-1)基因K121Q多态性与2型糖尿病合并视网膜病变的相关性。方法应用聚合酶链反应-限制性酶切片段长度多态性分析(PCR-RFLP)技术,对2型糖尿病合并视网膜病变(DR组,n=48)、2型糖尿病未合并视网膜病变(NDR组,n=56)进行PC-1基因K121Q多态性分型及研究,并与正常组(对照组组,n=56)对照分析。结果 DR组和NDR组KQ基因型频率、K等位基因频率均显著高于对照组组,差异有统计学意义(P<0.05);DR组和NDR组比较,KK型与KQ型基因型构成频率和等位基因频率差异无统计学意义(P>0.05)。结论 PC-1基因K121Q多态性与2型糖尿病相关,但其可能不是糖尿病视网膜病变发生的主要原因。Objective To investigate the relationship between K121 Q polymorphisms of the PC- 1（ plasma cell glycoprotein-1） gene and diabetic retinopathy. Methods K121 Q polymorphism of the PC- 1 gene was analyzed by cleaved amplification polymorphism sequence- tagged sites（ PCR- RFLP）,included patients with diabetic retinopathy（ DR,n = 48）,patients without diabetic retinopathy（ NDR,n = 48） and normal controls（ con,n = 56）. Results KQ genotype frequencies and Q allele carrier frequencies in DR and NDR were obviously higher than that in con（ P 〈 0. 05）. KK and KQ genotype frequencies and allele frequencies did not reveal any statistically significant difference between DR and NDR（ P 〉 0. 05）. Conclusion K121 Q polymorphisms of the PC- 1 gene is related to T2 DM,but it isn’t associated with Diabetic retinopathy.

关 键 词：糖尿病视网膜病变 浆细胞膜糖蛋白 K121Q多态性 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]