芬太尼与舒芬太尼用于腰硬联合分娩镇痛对产妇影响的比较  

The comparison of effects of fentanyl and sufentanil for combined spinal- epidural anesthesia analgesia on parturients

作　　者：陈友利[1] 曾丽蓉[1] 郭瑞[1] 

机构地区：[1]南方医科大学附属小榄人民医院,广东中山528415

出　　处：《黑龙江医药科学》2015年第1期32-34,共3页Heilongjiang Medicine and Pharmacy

摘　　要：目的:比较芬太尼与舒芬太尼用于腰硬联合麻醉分娩镇痛对产妇的影响。方法:选择ASAⅠ~Ⅱ级,年龄20~32岁,单胎、头位、足月妊娠初产妇260例进行分娩镇痛,随机分为两组:RF组(n=130),罗哌卡因+芬太尼,RS组(n=130)罗哌卡因+舒芬太尼。观察比较两组产妇的产程,镇痛效果,常见不良反应发生率。结果:两组患者潜伏期比较差异无统计学意义(P>0.05)。RS组与RF组在活跃期、第二产程、总产程差异有统计学意义(P<0.05),舒芬太尼组各期均显著短于芬太尼组。蛛网膜下腔注药后5min、10min、30min以及宫口开全时,RS组的VAS评分低于RF组(P<0.05),镇痛效果明显优于RF组。RS组与RF组的恶心、呕吐、皮肤瘙痒发生率比较差异有统计学意义(P<0.05),舒芬太尼组的常见不良反应显著低于芬太尼组。结论:舒芬太尼比芬太尼更能缩短产程,提高镇痛效果,减少常见不良反应发生率,更适合用于分娩镇痛。To compare the etfects of fentanyl and suientanil tor combined spinal - epidural anes- thesia analgesia on parturients. Methods： 260 cases of full - term pregnant women aged 20 to 32 on ASA I - II lev- el with single baby on head position, for labor analgesia were randomly divided into two groups：group RF （n = 130）, ropivacaine with fentanyl, group RS （n = 130） , ropivacaine with sufentanil. We compared parturient, in- trapartum analgesia effect, and rate of common adverse reactions between two groups. Results： Between two groups, there was no significant difference in latent phase （P 〉 O. 05 ）, but significant differences in the active phase, the second stage of labor and the whole parturient （ P 〈 0. 05 ）. The stages in sufentanil group v^ere signifi- cantly shorter than those in fentanyl group. After spinal anesthesia 5min、10min、30min and the time when mouth of womb wide was open, the VAS score in group RS was lower than that in RF group （P 〈 0. 05 ）. Analgesic effect was obviously better than that of RF group. The nausea, vomiting, skin itching occur rate in group RS and group RF had significant differences （ P 〈 0. 05 ）. Common adverse reaction of sufentanil group was significantly lower than that of fentanyl group. Conclusion： Compared with fentanyl, sufentanil can shorten birth process, improve analgesic effect, and reduce the adverse reaction rates. It is more suitable for labor analgesia.

关 键 词：分娩镇痛 罗哌卡因 舒芬太尼 芬太尼 腰硬联合麻醉 

分 类 号：R614.42[医药卫生—麻醉学]