普瑞巴林联合盐酸羟考酮治疗癌性神经病理痛33例  

Therapeutic Effects of Pregabalin Combined with Hydrochloric Oxycodone on 33 Cases of Malignant Neuropathic Pain

作　　者：章必成[1] 章志怀 王俊[3] 王志刚[1] 吴婷婷[1] 饶智国[1] 高建飞[1] 

机构地区：[1]广州军区武汉总医院肿瘤科,武汉430070 [2]湖北省黄冈市中心医院高压氧科,黄州438000 [3]济南军区总医院肿瘤科,济南250031

出　　处：《医药导报》2015年第3期325-328,共4页Herald of Medicine

摘　　要：目的评价普瑞巴林联合盐酸羟考酮治疗癌性神经病理痛(MNP)的疗效。方法将66例MNP患者随机分为两组各33例,对照组接受盐酸羟考酮治疗,治疗组接受盐酸羟考酮+普瑞巴林治疗。采用数字评估法(NRS)评分比较两组患者的止痛效果,采用MOS-SS睡眠量表(中文版)评价和比较两组患者的睡眠改善情况,采用17项汉密尔顿抑郁量表(HAMD-17)及汉密尔顿焦虑量表(HAMA)分别评定和比较两组患者的抑郁、焦虑状态,按世界卫生组织(WHO)抗癌药物急性与亚急性毒性分级标准评价两组的毒副反应。结果治疗组的疼痛缓解率为87.1%,明显优于对照组(58.6%)(P<0.05);治疗组患者在改善睡眠干扰、提升睡眠充足度及睡眠量等方面明显优于对照组(P<0.05);两组患者治疗后抑郁、焦虑状态均明显好转(P<0.01),且治疗组改善程度明显优于对照组(P<0.05);两组均无明显毒副反应。结论普瑞巴林联合盐酸羟考酮可以作为临床治疗MNP的优选方案。Objective To evaluate the effects of pregabalin combined with hydrochloric oxycodone on patients with ma-lignant neuropathic pain （MNP）. Methods A total of 66 patients with MNP was divided into control group or treatment group randomly. The patients in control group received only hydrochloric oxycodone, and treatment group were treated with the combina-tion of pregabalin and hydrochloric oxycodone. Numeric rating scale （NRS） score was used to evaluate the analgesic effects. Med-ical outcomes study sleep scale （MOS-SS,Chinese version） was used to evaluate the improvement of sleep disorder. The changes of depression or anxiety were investigated by 17-item Hamilton Depression Rating Scale （HAMD-17） or Hamilton Anxiety Scale （HAMA）, respectively. Side effects were accessed by Acute and Subacute Toxicity Grading Criteria of Anticancer Drugs （WHO）. Results The pain control rate of treatment group was 87. 1% , which was superior to that of control group （58. 6% ） （P〈0. 05）. The improvement of sleep interference, and the quality and quantity of sleep in treatment group were also superior to that in control group （P〈0. 05）. After the treatment, depression and anxiety was attenuated in both groups, and the improvement degree in treatment group was higher than that in control group （P〈0. 05）. No obvious side effects were found in either groups. Conclusion The combination therapy of pregabalin and hydrochloric oxycodone is the better way to treat MNP.

关 键 词：普瑞巴林 羟考酮 盐酸 神经病理痛 癌性 

分 类 号：R971.3[医药卫生—药品] R738.1[医药卫生—药学]