两种曲安奈德新型脂质载体经皮渗透性比较  

Comparison of Transdermal Penetration of Two New Kinds of Triamcinolone Acetonide Lipid Carriers

作　　者：王国强[1] 梁兆丰[1] 班俊峰[2] 邓广汉 林嘉成[1] 吕竹芬[1] 

机构地区：[1]广东省药物新剂型重点实验室/广东药学院药物研究所,广州510006 [2]广东药学院图书馆,广州510006

出　　处：《医药导报》2015年第3期361-365,共5页Herald of Medicine

基　　金：广东省教育厅科技计划资助项目(GCZXA0807)

摘　　要：目的比较曲安奈德(TAA)纳米脂质组装体(TAA-LPPs)、TAA乙醇脂质体(TAA-Ethosomes)的体外透皮特性。方法制备TAA-LPPs和TAA-Ethosomes,采用透射电镜观察其形态,激光粒度仪测定其粒径分布,改良Franz单室扩散池进行离体大鼠皮肤渗透实验,测定两种曲安奈德脂质载体的累积透过量及在皮肤内的滞留量。结果 TAALPPs和TAA-Ethosomes均呈球形或类球形,平均粒径分别为(99.9±1.3)和(105±1.4)nm。TAA-LPPs、TAA-Ethosomes和TAA-混悬液的累积透过量分别为(53.59±4.40),(87.03±4.87),(30.54±8.61)μg·(cm2)-1,32 h后皮肤内药物滞留分别为(1.02±0.13),(0.62±0.08),(0.55±0.17)μg·(cm2)-1。结论与TAA-Ethosomes比较,TAA-LPPs更利于曲安奈德经皮局部给药,减少药物全身吸收。Objective To compare transdermal penetration of triamcinolone acetonide liposparticles （TAA-LPPs） and TAA-Ethosomes in vitro. Methods The TAA-LPPs and TAA-Ethosomes were produced and the morphology was observed by transmission electron microscope,particle size was detected by laser particle analyzer. The percutaneous permeability in vitro was tested by modified Franz diffusion pools. The amount of penetrated triamcinolone acetonide and the retention in the skin were de-termined by HPLC. Results The shape of TAA-LPPs and TAA-Ethosomes was almost spherical with mean diameter of （99. 9±1. 3） and （105±1. 4） nm, respectively. The cumulative transdermal penetration of TAA-LPPs, TAA-Ethosomess and TAA suspension was （53. 59±4. 40）,（87. 03±4. 87）,and （30. 54±8. 61） μg·（cm^2 ）^ -1 , respectively . The drug retention in the skin after 32 h was （1. 02±0. 13）, （0. 62±0. 08）, （0. 55±0. 17） μg·（cm^2 ） ^-1 , respectively. Conclusion TAA-LPPs is better for transdermal administration of triamcinolone acetonide by reducing systemic absorption of the drug.

关 键 词：曲安奈德 纳米脂质组装体 乙醇脂质体 经皮渗透 

分 类 号：R944.9[医药卫生—药剂学] R986[医药卫生—药学]