1-(2,4二异丙氧基-5-甲氧苯基)乙酮的合成研究  

Synthesis of 1-( 2,4-diisopropoxy-5-methoxyphenyl) ethanone

作　　者：王爱玲[1,2] 陶波[1] 

机构地区：[1]东北农业大学农学院,黑龙江哈尔滨150030 [2]大连大学环境与化学工程学院,辽宁大连116622

出　　处：《化学研究与应用》2015年第3期354-357,共4页Chemical Research and Application

基　　金：杂草抗药性监测及治理技术研究与示范项目(201303031)资助;公益性行业(农业)科研专项项目资助

摘　　要：本文设计一条新的合成路线,以价廉的异香兰素、间苯二酚为起始原料,通过Dakin反应、乙酰化、酚羟基醚化等系列反应得到目标化合物1-(2,4二异丙基氧基苯基)乙酮(5b)和新化合物1-(2,4二异丙基氧基-5-甲氧基苯基)乙酮(5a)。通过对化合物(5a)进行条件因素探索,得出合成(5a)的最佳反应条件,并通过1H NMR、MS、熔点等技术手段对其进行结构的确认与表征。A new synthetic route was designed in this paper. The target compounds of 1-（ 2,4-diisopropoxy-5-methoxyphenyl） ethanone（ 5a） and 1-（ 2,4-diisopropoxyphenyl） ethanone（ 5b） were synthesized by Dakin reaction,acetylation reaction and etherification of the phenolic hydroxyl with the raw material 3-hydroxy-4-methoxybenzaldehyde and benzene-1,3-diol. The compound 5a was new compound. The influents on the yields of compound 5a were investigated and the best reaction conditions were obtained. The structures of compound 5a and 5b were characterized by means of1 H NMR,MS,and melting point.

关 键 词：1-(2 4二异丙基氧基苯基)乙酮 1-(2 4二异丙基氧基-5-甲氧基苯基)乙酮 香豆素 合成 

分 类 号：O626.323[理学—有机化学]