免疫调节在骨质疏松症中的研究进展  

The Research Progress of Immunomodulatory in Osteoporosis

作　　者：李文艳[1] 徐玉善[1] 李红[1] 

机构地区：[1]昆明医科大学第一附属医院内分泌一科,昆明650000

出　　处：《医学综述》2015年第2期213-216,共4页Medical Recapitulate

基　　金：云南省卫生科技项目(2010NS037)

摘　　要：骨质疏松症的原因包括内分泌因素、营养状况、遗传因素、物理因素、免疫因素等。近年来研究表明,免疫系统和骨骼系统之间存在密切联系,免疫细胞和骨细胞都处于骨骼腔的微环境中,它们共享有很多调节分子,包括细胞因子及其受体、信号分子和转录因子等。免疫细胞能分泌大量细胞因子,可以促进破骨细胞的数量增多、活性增强,骨质吸收增加。该文就调节性T细胞、白细胞介素17、辅助性T细胞17等细胞因子在骨质疏松中的作用进展作一综述,以期进一步阐述免疫调节在骨质疏松症的发生、发展中的作用。There were several causes,such as endocrine factors,nutritional situation,genetic factors,physical factors,and immune factors for osteoporosis. In recent years,studies have shown that there is a close link between the immune system and the skeletal system. Immune cells and bone cells are in the same bone microenvironment,and they share many common regulatory molecules,including cytokines and their receptors,signaling molecules and transcription factors. Immune cells can secrete large amount of cytokines which can promote the increasing of number and activity of osteoclasts,and can enhance the resorption of bone. Here is to make a review of the role of cytokines in the osteoporosis,such as regulatory T cells,IL-17,Th17,and further elaborate the effect of immunomodulatory on the development of osteoporosis.

关 键 词：骨质疏松症 免疫系统 破骨细胞 调节性T细胞 

分 类 号：R274[医药卫生—中医骨伤科学]