调节性B细胞在癌症中的研究进展  

Research Progress of Regulatory B Cells in Cancer

作　　者：张天[1,2] 孙素红[1] 

机构地区：[1]遵义医学院附属医院甲乳外科,贵州遵义563000 [2]贵州省免疫学研究生教育创新基地,贵州遵义563000

出　　处：《医学综述》2015年第2期236-238,共3页Medical Recapitulate

基　　金：贵州省遵义市政红花岗区2010科学技术项目;教育部新世纪人才项目(NCET-10-0095)

摘　　要：B淋巴细胞是人体特异性免疫的重要组成部分,其主要功能是抗原呈递以及分泌抗体。新近研究发现,调节性B细胞(Bregs)通过分泌白细胞介素10和转化生长因子β1等细胞因子作用于免疫系统,在炎症、自身免疫性疾病以及癌症进展、转归和预后中发挥作用。了解Bregs在癌症中的作用机制对临床治疗癌症具有重要意义。该文就Bregs与癌症的关系及其研究进展予以综述。B lymphocytes are an important part of the specific immune in the body,and its main function is to present antigen and secrete antibody. Recent studies have found that,Bregs act on the the immune system through the secretion of IL-10 and TGF-β1cytokines,and play a role in inflammation,autoimmune disease,and cancer progression,outcome and prognosis. Understanding the role of Bregs in cancer mechanism is of great significance to the clinical treatment. Here is to make a review of the research progress in the relationship between the Bregs and cancer.

关 键 词：癌症 调节性B细胞 肿瘤免疫 

分 类 号：R392[医药卫生—免疫学]