血小板源性生长因子C和D在肾脏疾病中的研究进展  

Research Progress of PDGF-C and PDGF-D in Kidney Diseases

作　　者：徐聪[1] 刘云启[1] 

机构地区：[1]滨州医学院附属医院肾内科,山东滨州256603

出　　处：《医学综述》2015年第5期789-791,共3页Medical Recapitulate

摘　　要：血小板源性生长因子(PDGF)家族可调节多种病理生理活动,在肾脏中属于最典型的生长因子系统,并且越来越多的证据表明PDGF家族是多种肾脏疾病发展的关键因素。PDGF-C和PDGF-D是新发现的PDGF家族的两个亚型,与PDGF-A和PDGF-B在结构和功能上有一定差异,其在胚胎发育、恶性肿瘤、伤口愈合、动脉粥样硬化以及多个器官的纤维化中起重要作用。The platelet-derived growth factor （ PDGF） family regulates multiple pathophysiologic events , and it belongs to the most typical growth factor systems of kidney ,and there are more and more evidence indica-ting that PDGF family is the key factor of the development of multiple renal diseases .Recently, two new mem-bers of the PDGF-family were discovered, namely PDGF-C and PDGF-D,they were different from PDGF-A and PDGF-B in structure and function.PDGF-C and PDGF-D play important roles in embryonic development, malignancy,wound healing,atherosclerosis, and fibrosis of multiple organs.

关 键 词：肾脏疾病 血小板源性生长因子C 血小板源性生长因子D 

分 类 号：R692[医药卫生—泌尿科学]