氰氨化钙合成药物对血吸虫虫卵形态学影响  

Effect of calcium cyanamid synthetic drug on Schistosoma japonicum egg morphology

作　　者：周义生[1] 彭国华[1] 胡主花[1] 冯小武[1] 朱蓉[2] 魏望远[3] 郭家钢[2] 

机构地区：[1]南昌市疾病预防控制中心,南昌330038 [2]中国疾病预防控制中心寄生虫病预防控制所,卫生部寄生虫病原与媒介生物学重点实验室,世界卫生组织疟疾,血吸虫病和丝虫病合作中心 [3]湖南省血吸虫病防治所

出　　处：《中国血吸虫病防治杂志》2015年第1期56-58,共3页Chinese Journal of Schistosomiasis Control

基　　金：江西省卫生和计划生育委员会项目(20133191)

摘　　要：目的观察虫卵经氰氨化钙合成药物作用后的形态改变,为进一步研究氰氨化钙合成药物杀灭血吸虫虫卵作用机理提供依据。方法向含有血吸虫虫卵的阳性牛粪中加入氰氨化钙合成药物并搅拌,模拟野粪自然形态堆放于洲滩上;同时设空白对照。于1、2、3、7 d后分别取样,收集血吸虫虫卵,于显微镜下观察虫卵形态。结果虫卵经氰氨化钙合成药物作用后,颜色逐步加深,毛蚴萎缩,卵壳变厚,3 d后胚膜不完整,7 d后毛蚴严重变形;对照组毛蚴未见明显萎缩。结论氰氨化钙合成药物对虫卵胚膜及毛蚴有损伤作用,且随时间延长而损伤加重。Objective To study the morphological change of Schistosoma japonicum eggs processed by calcium cyanamide synthetic drug, so as to provide the basis for further study of the mechanism that calcium cyanamide synthetic drug to schisto- some eggs. Methods The calcium cyanamide synthetic drug was added to the cattle feces containing schistosome eggs and mixed up, and then the cattle feces was stacked as original shape on the marshland. Blank controls were set at the same time. The cattle feces samples were collected and the schistosome eggs were observed under a microscope on the 1st, 2nd, 3rd, 7th day after the experiment. Results By the effect of calcium cyanamide synthetic drug, the color of eggs was deepening gradual- ly, the miracidia were atrophied, and the shells of eggs were thickened. The embryonic membrane of miracidia was no longer completed 3 days later, and the miracidia were deformed severely 7 days later. The atrophy of miracidia was not obvious in the blank controls. Conclusion The schistosome miracidia and embryonic membrane can be damaged by the calcium cyananfide synthetic drug, and worse damaged with time extending.

关 键 词：血吸虫虫卵 氰氨化钙 药物 形态 影响 

分 类 号：R383.24[医药卫生—医学寄生虫学]