氯硝柳胺的细胞毒性机制研究  

Researches on mechanism of cell toxicity caused by niclosamide

作　　者：徐颖[1] 戴建荣[1] 

机构地区：[1]江苏省血吸虫病防治研究所,卫生部寄生虫病预防和控制技术重点实验室,江苏省寄生虫分子生物学重点实验室,无锡214064

出　　处：《中国血吸虫病防治杂志》2015年第1期104-107,共4页Chinese Journal of Schistosomiasis Control

基　　金：国家自然科学基金(81071379);江苏省领军人才(LJ201132)

摘　　要：氯硝柳胺是最常用的灭螺药物。随着该药物的大量应用,对其水生生物毒性作用及细胞毒性机制的研究越来越多。本文对氯硝柳胺引起的细胞、细胞器、细胞酶、细胞信号通路及遗传物质毒性进行了概述,并提出了今后的研究方向。Niclosamide is the most commonly used molluscicide. Along with a lot of application of niclosamide, more and more scientists studied its toxic effects to aquatic organisms as well as the related cell toxicity mechanism. This paper summariz- es the toxicity on cell, organelle, enzyme, cell signaling pathway, and genetic material caused by niclosamide, and puts for- ward the future research direction.

关 键 词：氯硝柳胺 细胞 毒性 机制 

分 类 号：R383.2[医药卫生—医学寄生虫学]