BML-111对野百合碱致大鼠肺动脉高压的作用及其机制的研究  

作　　者：陈永梅[1] 张昭勇[1] 陈玲[1] 向勇[1] 秦成名[1] 

机构地区：[1]湖北医药学院附属太和医院,442000

出　　处：《浙江临床医学》2015年第3期340-341,共2页Zhejiang Clinical Medical Journal

基　　金：湖北省十堰市科技局指导项目（ZD20111016）

摘　　要：目的观察脂氧素受体激动剂BML-111对野百合碱（MCT）诱导肺动脉高压大鼠的作用及其机制。方法选择SD大鼠24只，随机分为三组：C组、pH组、B组，pH组和B组大鼠行皮下注射野百合碱50μg／g，C组注射等量生理盐水，B组腹腔注射BML-1111mg／（kg·d），连续4周。观察平均肺动脉压力（MPAP）、右心室收缩压（RVSP）、右心室（RV）／[左室（LV）＋室间隔（S）]、肺组织白介素．6（IL-6）和肿瘤坏死因子-α（TNF-α）水平的变化。结果pH组、B组与C组比较，MPAP、RVSP、RV／（LV＋S）、肺组织IL-6及TNF-α水平高于C组（P〈0．05）；B组与pH组比较，MPAP、RVSP、RV／（LV＋S）、肺组织IL-6及TNF-α低于pH组（P〈0．05）。结论脂氧素受体激动剂BML-111可减轻野百合碱诱导肺动脉高压大鼠肺动脉压力，其机制可能与减轻肺组织IL-6及TNF-α水平，抑制肺组织炎症有关。Objective To investigate the effect ofBML-111 on rats pulmonary arterial hypertension induced by monocrotaline and mechanisms. Methods 24SD rats were randomly allocated into three groups： C group, pH group and B group, Both pH group and B group processed subcutaneous injection of 50 μg/g monocrotaline while C group received same volume of saline, B group performed intraperitoneal injection of BML- 1111mg/kg/d from the day immediately as monocrotaline was injected. The observation： MPAP, RVSP, RV/ （LV＋S） , the pulmonary tissue IL-6 and TNF-α. Results The pH group and B group developed higher level of MPAP, RVSP, RV/ （ LV＋S ） , the pulmonary 1L-6 and TNF-α as compared with C group （ P〈0.05 ） , B group got lower increase of MPAP, RVSP, RV/ （ LV＋S ） , the pulmonary IL-6 and TNF-α as compared with pH group （ P〈0.05 ） . Conclusions BML- 111 can ameliorate pulmonary arterial hypertension, inhibition of the pulmonary tissue inflammation may be a potential cause.

关 键 词：脂氧素受体激动剂 野百合碱 肺动脉高压 大鼠 

分 类 号：R543.2[医药卫生—心血管疾病]