新型苦参碱衍生物的合成  

Synthesis of Novel Matrine Derivatives

作　　者：梁鹏云[1] 刘旭[1] 张敏[1] 周艳玲[1] 周永红[1] 蒋敏捷[1] 王立升[1] 

机构地区：[1]广西大学化学化工学院,广西南宁530004

出　　处：《合成化学》2015年第3期219-222,共4页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21262005);广西自然科学基金资助项目(2012GXNSFAA053158)

摘　　要：以苦参碱为原料,经内酰胺水解,酯化和氯代3步反应合成了关键中间体——16-N-(氯乙酰基)-苦参酸酯(5);5分别与N-苯基哌嗪衍生物反应合成了8个新型的苦参碱衍生物,其结构经1H NMR,IR和ESI-MS表征。Two key intermediate, 16-N-（chloroacetyl） -matrine acid este,（ 5）, were prepared by a three-step reaction of lactarn hydrolysis, esterification and chlorination from matrine. Eight novel ma- trine derivatives were synthesized by the reaction of 5 with N-phenyl-piperazine derivatives, respec- tively. The structures were characterized by 1H NMR. IR and ESI-MS.

关 键 词：苦参碱 哌嗪 衍生物 合成 

分 类 号：O626.4[理学—有机化学]