哺乳动物抗菌肽的生物信息学预测与分析  

Bioinformatics prediction and analysis of mammalian antimicrobial peptides

作　　者：王艳[1] 丁雪[1] 赵晶[1] 宋明霞[1] 杜丰平 周晓馥[1] 

机构地区：[1]吉林师范大学生命科学学院,吉林四平136000

出　　处：《广东农业科学》2015年第3期131-133,139,共4页Guangdong Agricultural Sciences

基　　金：吉林省科技厅发展计划项目(20130206059NY)

摘　　要：抗菌肽(Antimicrobial peptides,AMPs)是能够抵抗病源微生物的小分子多肽,广泛分布于动植物、细菌、真菌等各种生物中,其在天然免疫中起着重要的作用。利用生物信息学方法,结合两大生物信息学门户网站ExPASy和NCBI,对截至2013年4月27日NCBI上所有的哺乳动物抗菌肽条目的上述性质进行了详细分类,并对其氨基酸长度、平均疏水性、跨膜结构、信号肽、亚细胞定位等特征进行预测及分析。Antimicrobial peptides（antimicrobial peptides, AMPs） are small peptides which are widely distributed in plants, animals, bacteria, fungi and other organisms. They play important role in innate immunity. Bioinformaties methods were used combined with the two portals, ExPASy and NCBI to carry out a detailed classification of all mammalian AMPs. Moreover, their amino acids in length, the average hydrophobicity, transmembrane, signal peptide, subcellular localization and other features were also predicted and analyzed.

关 键 词：哺乳动物抗菌肽 生物信息学 预测 分析 

分 类 号：Q518.1[生物学—生物化学]