痰热清注射液治疗慢性支气管炎急性发作临床研究  

Clinical Efficacy of Tanreqing Injection for Acute Episode of Chronic Bronchitis and Its Effect on Bacterial Clearance Rate

作　　者：王静[1] 原杰[1] 张灼[1] 孙丽萍[1] 郑伟[1] 

机构地区：[1]解放军第二炮兵总医院,北京100088

出　　处：《中国中医药信息杂志》2015年第4期26-28,共3页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的观察痰热清注射液联合左氧氟沙星注射液治疗慢性支气管炎急性发作(AECB)的临床疗效及对细菌清除率的影响。方法将66例AECB患者随机分为治疗组和对照组各33例,2组均予西医常规祛痰、解痉治疗,治疗组在此基础上予痰热清注射液联合左氧氟沙星注射液,对照组予左氧氟沙星注射液,连用12 d。观察2组治疗前后临床症状、体征变化,并进行痰培养,比较2组临床疗效及细菌清除率。结果治疗组总显效、总有效例数分别为15、29例,对照组分别为7、21例,组间比较差异有统计学意义(P<0.05)。治疗组、对照组细菌清除率分别为89.5%(17/19)、55.6%(10/18),差异有统计学意义(P<0.05)。结论痰热清注射液与左氧氟沙星注射液联合治疗AECB的临床疗效优于单独应用左氧氟沙星注射液。Objective To observe the clinical efficacy of Tanreqing Injection combined with levofloxacin injection in treatment of acute episode of chronic bronchitis and its effect on bacterial clearance rate. Methods Totally 66 patients were randomly divided into treatment group and control group （33 cases for each）. Both groups were given expectorant and antispasmodic treatment. The treatment group was given Tanreqing Injection combined with levofloxacin injection, while the control group was given levofloxacin injection only. The treatment course was 12 days. The clinical symptoms, signs, and sputum culture before and after treatment were observed. The clinical efficacy and the bacterial clearance rate of the two groups were compared. Results The markedly effective cases and the effective cases in the treatment group were 15 and 29 respectively, and those in the control group were 7 and 21 respectively, with statistical significance （P〈0.05）. The bacterial clearance rate was 89.5% （17/19） in the treatment group, while 55.6%（10/18） in the control group, with significant difference （P〈0.05）. Conclusion Acute episode of chronic bronchitis treated by Tanreqing Injection combined with levofloxacin injectcion is more effective than levofloxacin injection only.

关 键 词：慢性支气管炎急性发作 痰热清注射液 左氧氟沙星注射液 临床疗效 细菌清除率 

分 类 号：R259.622.1[医药卫生—中西医结合]