微波消解-ICP-MS法测定药用明胶空心胶囊中微量重金属元素  

Determination of Trace Heavy Metal Elements in Vacant Gelatin Capsules by ICP-MS with Microwave-Asisted Digestion

作　　者：邱丽[1] 施意华[1] 唐碧玉[1] 靳小珠 古行乾[1] 

机构地区：[1]中国有色桂林矿产地质研究院有限公司测试中心,广西桂林541004

出　　处：《中国无机分析化学》2015年第1期7-10,共4页Chinese Journal of Inorganic Analytical Chemistry

基　　金：广西科学研究与技术开发计划项目(14-87-01)资助

摘　　要：采用微波消解技术,建立了一种电感耦合等离子体质谱法测定明胶空心胶囊中Cr,Co,Ni,Cu,Zn,As,Cd,Hg和Pb 9种微量重金属元素的方法.确定了微波消解仪和等离子体质谱仪的最佳操作参数,研究共存离子的干扰和消除方法,选择了各元素的测定同位素,以Ge,Rh和Tl为内标补偿基体效应,建立了样品测定方法.应用拟定的方法测定了不同生产厂家、不同批次的空心胶囊中微量重金属的含量.方法对试样中各元素测定的相对标准偏差为1.5％～14.1％,加标回收率在90.0％～102.0％.结果表明,方法简便、快速、灵敏,满足于空心胶囊中9种重金属元素的测定要求.A method for the determination of the contents of 9 trace heavy metal elements of Cr,Co,Ni, Cu,Zn,As, Cd, Hg and Pb in vacant gelatin capsules by inductively coupled plasma mass spectrometry （ICP-MS） after microware-assisted digestion was established. Analytical conditions for microwave digestion and ICP-MS instrumental operation were optimized. The interference from coexistent ions on determination of 9 elements and the interference eliminating methods were studied. 72Ge, 103Rh and 20ST1 were chosen as internal standards to compensate matrix effects. By applying the proposed method, the contents of 9 trace heavy metal elements in vacant capsules from different factories and different batches were determined. The relative standard deviations （RSD） were in the range of 1.5%~14. 1% with 90.0% ~102.0% recoveries. The results indicate that the proposed method is simple, rapid and sensitive, and is suitable for the determination of the contents of 9 trace heavy metal elements in vacant capsules.

关 键 词：空心胶囊 微量重金属元素 电感耦合等离子体质谱法 微波消解 

分 类 号：O657.63[理学—分析化学] TH843[理学—化学]