促进转录因子Nrf2表达的中药文献分析——体内抗氧化药物筛选  

Analysis of Traditional Chinese Medicine Literature Based on Promoting the Expression of Transcription Tactor Nrf2-antioxidant Drug Filter in the Body

作　　者：廖系晗[1] 胡人月[1] 张小梅[1] 张艳[1] 梁旭明[1] 金仕勇[1] 叶华群[1] 张晋[1] 

机构地区：[1]重庆市中药研究院,重庆400065

出　　处：《中医药导报》2015年第7期76-79,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:探讨刺激转录因子Nrf2信号通路,调节肌体抗氧化、促还原的药食中药,确定药名。方法:采用中国期刊全文专题数据库(CNKI)等以关键词"转录因子Nrf2""中药筛选""文献分析"进行检索,按照纳入和排除标准筛选2004-2014年公开发表的文献,用Excel2007创建文献题录库,存储、提取数据;建立文献计量统计分析与多指标评价相结合的方法:抗氧化,影响Ⅱ相解毒酶与蛋白激酶(GST、UGT、NQO1、GSH、ERK、JNK)活性,刺激Nrf2诱导Ⅱ相解毒酶表达,比较中药刺激Nrf2的强弱。结果:纳入符合要求的文献共计57篇,包括中药28种,化合物40种,疾病16种。结论:筛选出22种与指标评价相符的药物,其中刺激Nrf2诱导Ⅱ相解毒酶表达最强的中药为姜黄、洋甘菊、红车轴草。Objective： To explore the signal pathway of stimulate transcription factor Nrf2, regulating the body antioxidant, promoting the reduction of medicinal and edible Chinese herbal medicine, and making sure the drug name. Methods： ＂tran- scription factor Nrf2＂, ＂Chinese medicine screen＂ and ＂literature analysis＂ were used as keywords to retrieve by using China journal full-text database （CNKI）, et al. According to include and exclude standards, the published literatures were selected during 2004-2014. To create literature documents, storage and extract the data using Excel 2007, and establish method through qualitative analysis combined with multi-index evaluations： oxidation,influence Ⅱ detoxifying enzymes and protein ki- nase （GST, UGT, NQO1, GSH, ERK and JNK） activity,stimulate Nrf2 induction Ⅱ detoxifying enzyme expression, and com- pare the strength of the traditional Chinese medicine to stimulate the Nrf2. Results： According to the requirement references, 57 literatures were included, including 28 kinds of Chinese medicine, 40 kinds of compounds, and 16 kinds of disease. Conclusion： There were 22 kinds of drugs screened,which were matching the index evaluation, and the strongest expression of traditional Chinese medicine for the stimulus Nrf2 induction Ⅱ phase detoxifying enzyme are turmeric, chamomile and trifolium pratense.

关 键 词：转录因子Nrf2 文献分析 抗氧化 药物筛选 

分 类 号：R284[医药卫生—中药学]