自然杀伤T细胞失能的相关研究进展  

Research on natural killer T cells anergy

作　　者：林生力[1] 易拓[1] 牛伟新[1] 

机构地区：[1]复旦大学附属中山医院普外科,上海200032

出　　处：《国际外科学杂志》2015年第1期60-63,共4页International Journal of Surgery

摘　　要：自然杀伤T细胞同时表达自然杀伤细胞和T细胞受体,发挥免疫调节和细胞毒作用.相关研究证实激活自然杀伤T细胞可以抑制肿瘤进展,但短暂活化的自然杀伤T细胞常常因为未知原因迅速进入失活状态.本文就目前自然杀伤T细胞失能可能机制及应对措施的研究进展作一综述.Natural killer T（NKT） cells are a heterogeneous group T cells that share properties of both natural killer cells and T cells,play an important role in tumor immunity.Related researches have confirmed that actived NKT cells can inhabit tumor progress,but activated NKT cells commonly become anergic for some unknown reasons after a short time.This article reviews researches on the possible mechanisms and solutions to NKT cells anergy.

关 键 词：自然杀伤T细胞 肿瘤免疫 α半乳糖基神经酰胺 

分 类 号：R392.12[医药卫生—免疫学]