LC-MS/MS法测定纸质包装材料中15种光引发剂向改性聚苯醚模拟物的迁移量  

Determination of Migration of the 15 Photoinitiators from Paper-Made Packing Using Modified Polyphenylene Oxide as a Simulant by LC-MS/MS

作　　者：刘珊珊[1] 李中皓[1] 杨飞[1] 柯玮[1] 刘岩顺 范子彦[1] 王颖[1] 边照阳[1] 唐纲岭[1] 陈再根[1] 

机构地区：[1]国家烟草质量监督检验中心,河南郑州450001

出　　处：《质谱学报》2015年第2期168-176,共9页Journal of Chinese Mass Spectrometry Society

基　　金：中国烟草总公司标准项目专项(512013AB0050;562014AB0040);国家烟草质量监督检验中心科技项目(512013CA0110)资助

摘　　要：为了考察光引发剂的迁移特性,评估安全风险,建立了一种基于液相色谱-串联质谱（LC-MS/MS）分析纸质包装材料中15种光引发剂向改性聚苯醚（MPPO）模拟物迁移量的方法。纸质包装材料中迁移出的被分析物被MPPO吸附后用乙腈萃取,萃取液经有机滤膜过滤后,采用乙腈和0.1%甲酸水溶液作为流动相进行梯度洗脱,Luna PFP（2）色谱柱（150mm×4.6mm×3μm）分离,串联质谱法分析,外标法定量。通过对色谱条件优化,15种光引发剂在12min内可实现有效分离,且目标分析物在0.01-0.2mg/kg范围内线性关系良好,线性相关系数R^2〉0.993。3个加标水平（0.01、0.05和0.2mg/kg）的回收率在70.2%-122.5%之间,相对标准偏差（RSD）小于7.5%,检出限（LOD）为0.001-0.021mg/kg。实际样品的分析结果表明,该方法的检出限低、测定结果准确,可用于纸质包装材料中15种光引发剂向改性聚苯醚模拟物迁移量的检测。In order to investigate the migration behavior of the PIs for the security risk assessment, the migrations of 15 photoinitiators （Pls） from paper-made packing using modified polyphenylene oxide （MPPO） as a simulant were determined using liquid chro matography tandem mass spectrometry （LC-MS/MS）. MPPO, which was adsorbed the Pls migrated from paper-made packing, was extracted using acetonitrile, followed by clean-up of extract using organic phase filter. The Pls were separated in 12 min on the column of I.una PFP（2） by gradient elution with acetonitrile and water with 0.1 % formic acid as mobile phase. All the PIs have good linear relationship （R^2〉0. 993） with in 0.01-0.2 mg/kg. The recoveries of 15 Pls are in the range of 70.2%-122.5% at the spike levels of 0.01, 0.05 and 0.2 mg/kg with the relative standard deviation less than 7.5%. The limits of detection range from 0.001 to 0.021 mg/kg. The analysis of real sample shows that the method with high sensitivity and high accuracy can be applied for the determination of migration of Pls from paper-made packing.

关 键 词：光引发剂 改性聚苯醚 液相色谱-串联质谱(LC-MS/MS) 纸质包装材料 

分 类 号：O657.63[理学—分析化学]