葛根总黄酮对醉酒小鼠自主活动及血清中乙醇浓度的影响  

The Effect of Pueraria Lobata Flavone on Autonomous Activity and Serum Alcohol Concentration in Drunken Mice

作　　者：刘建兴[1] 何进勇[1] 李耿[1] 吴庆光[1] 

机构地区：[1]广州中医药大学,广东广州510006

出　　处：《中医药导报》2015年第5期42-44,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:研究葛根总黄酮对急性酒精中毒小鼠自主行为活动的影响。方法:小鼠分别以浓度为500 mg/kg、250 mg/kg、125 mg/kg的葛根总黄酮灌胃,灌胃体积均为0.2 m L/10 g。灌胃给药后30 min,按0.14 m L/10 g体质量给予56%红星二锅头,造成醉酒模型。测定小鼠攀附时间、睡眠潜伏时间、睡眠时间,酒后不同时间段的自主活动次数,并测定小鼠血清中乙醇浓度。结果:葛根总黄酮能明显延长小鼠攀附时间、延长小鼠睡眠潜伏时间,缩短醉酒小鼠的睡眠时间,减少醉酒后小鼠的活动次数,降低醉酒小鼠血清中乙醇浓度。结论:葛根总黄酮能有效预防醉酒,降低醉酒后小鼠的兴奋性,使躁烦症状减轻。Objective： To research the effect of Pueraria lobata flavone on acute alcoholism intoxicated mice autonomous ac- tivities. Methods： Mice were oral given Pueraria lobata flavone at 500 mg/kg, 250 mg/kg and 125 mg/kg, with gavage doses of 0.2 mL/10 g. Drunkenness model was caused by oraled 56° hongxing wine with 0.14 ml/10 g, 30minutes after oral administration. The cling time, sleep latency, sleep time were determined. And independent activity frequency after drink in different periods and ethanol concentration in serum were determined. Results： Kudzu flavonoids can significantly prolong cling time, prolong sleep latency, shorter sleep time of drunken mice, decrease the number of activity, and reduce drunken mouse serum ethanol concen- tration of drunken mice. Conclusion： Kudzu flavonoids were effective in preventing drunk, reducing the excitability, and alleviat- ing restlessness symptoms of drunken mice.

关 键 词：葛根总黄酮 自主活动 血清乙醇浓度 醉酒小鼠 

分 类 号：R285.5[医药卫生—中药学]