北五味子醇提物对记忆获得障碍模型小鼠记忆能力的影响  

The behavioral effects of schisandra Chinensis baill extract on acquired learning and memory disorder of mice

作　　者：徐博[1] 安英[1] 沈楠[1] 赵丽晶[1] 陈雪[1] 段大航[2] 陈建光[2] 

机构地区：[1]吉林医药学院机能学实验室,132013 [2]北华大学药理教研室,132013

出　　处：《中国老年保健医学》2015年第1期35-36,共2页Chinese Journal of Geriatric Care

摘　　要：目的探讨北五味子醇提物(SCE)对东莨菪碱致小鼠记忆获得障碍的影响。方法将小鼠随机分为空白组、模型组、SCE组(低、中、高剂量组)和阳性药对照组(吡拉西坦),分别灌胃给药之后造模并进行跳台测试;应用分光光度法测定SCE对东莨菪碱所致记忆获得障碍模型小鼠血清和脑组织中乙酰胆碱脂酶(ACh E)活性的影响。结果 SCE组小鼠学习记忆成绩较模型组有显著提高;降低东莨菪碱所致记忆获得障碍模型小鼠血清和脑组织中乙酰胆碱脂酶(ACh E)的含量。结论 SCE对东莨菪碱造成的记忆获得障碍小鼠的学习记忆能力有明显的改善作用。Objectives To observe the effects of Schisandra Chinensis Baill Extract （SCE） on acquired learning and memory dis-order of mice.Methods Mice were randomly divided into six groups：normal concrol , model concrol , piracetam and schisandra chinensis baill extract at small ,middle,and high doses.Step-down test was used to observe effects of SCE on acquired learning and memory disorder induced by scopolamine in mice , Spectrophometry was used to measure effects of SCE on acetycholinesterase （ AChE） activities in serum and brain of mice with acquired learning and memory disorder induced by scopolamine .Results SCE would significantly improve the learning and memory abilities of mice ,reduce AChE activities in the brain and serum of mice with ac-quired learning and memory disorder induced by scopolamine .Conclusions SCE would improve the learning and memory abilities of mice induced by scopolamine .

关 键 词：北五味子醇提物 记忆获得障碍 乙酰胆碱脂酶 

分 类 号：R285.5[医药卫生—中药学]