硫酸羟胍的绿色合成工艺研究  

Study on Green Synthesis Technology of Hydroxyguanidine

作　　者：何晓强[1] 李安梅[1] 朱士荣[1] 

机构地区：[1]荆楚理工学院化工与药学院,湖北荆门448000

出　　处：《化学与生物工程》2015年第3期60-61,共2页Chemistry & Bioengineering

基　　金：荆门市科技局社发科项目(2012YD01);湖北省教育厅科研计划资助项目(B2013164);湖北省教育厅高等学校优秀中青年科技创新团队计划资助项目(T200911)

摘　　要：以硫酸羟胺为原料、水为溶剂、O-甲基硫酸异脲为胍基化试剂合成硫酸羟胍。确定了适宜的反应条件为:反应温度0℃、反应时间8h、O-甲基硫酸异脲和硫酸羟胺的物质的量比为1.10、以甲醇-水(3∶7,体积比)为重结晶溶剂,在此条件下,硫酸羟胍收率为54.2%。优于传统工艺,是一种绿色清洁合成技术。Hydroxyguanidine was synthesized using hydroxylamine sulfate as material,water as solvent,and O-methylisourea hemisulfate as guanidinylation reagent.The optimal reaction conditions were determined as follows：reaction temperature was 0 ℃,reaction time was 8h,molar ratio of O-methylisourea hemisulfate to hydroxylamine sulfate was 1.10,recrystallization solvent was methanol-water（3∶7,volume ratio）.Under above conditions,the yield was 54.2%.This process is superior to the traditional process,and it is a green clean synthesis technology.

关 键 词：硫酸羟胍 O-甲基硫酸异脲 硫酸羟胺 绿色合成 

分 类 号：O613.61[理学—无机化学]