布地奈德每天持续和间歇性雾化吸入预防儿童哮喘发作的疗效比较  

作　　者：吴振波[1] 周芳[1] 林如仲 

机构地区：[1]广东省江门市妇幼保健院(江门市儿童医院),广东529000

出　　处：《当代医学》2015年第8期137-138,共2页Contemporary Medicine

摘　　要：目的：比较分析每天持续和间歇性雾化吸入布地奈德预防儿童哮喘发作的疗效。方法选取年龄3～5岁哮喘患儿86例，根据患儿家庭经济状况、依从性等因素分为A组（n=42）和B组（n=44）。A组患儿在无症状的哮喘维持治疗期给予1次/d低剂量（0.5 mg）雾化吸入布地奈德吸入混悬液；B组患儿在哮喘维持治疗期无症状时不需要进行任何治疗，父母在观察患儿发生气喘症状前，确认有前兆呼吸道疾病症状或表现时（如咳嗽、鼻塞、流涕、胸闷等），即开始给患儿进行雾化吸入治疗，给药方案为间歇性高剂量方案（在先于喘息发作的早期呼吸道疾病症状即开始吸入布地奈德吸入混悬液，剂量1 mg，2次/d，持续7 d）。研究以哮喘急性发作需口服或静脉使用糖皮质激素治疗为终点。观察2组需要口服或静脉使用糖皮质激素用药的急性发作频率的差异，首次急性发作的时间、第2次急性发作的时间及治疗失败率，呼吸道疾病期间的症状和急性发作期间的症状。结果对于减少哮喘急性发作，每天低剂量布地奈德方案并不优于间歇性高剂量布地奈德方案。结论布地奈德吸入混悬液1 mg，2次/d、间歇性高剂量雾化吸入治疗，连续7 d用于预防儿童哮喘发作时具有有效性，疗效与1次/d低剂量（0.5 mg）持续吸入无明显差异，而且间歇性高剂量方案中布地奈德平均暴露量比每天持续吸入少。Objective Comparative analysis the daily continuous and intermittent atomization inhalation budesonide the curative effect of prevention of asthma in children. Methods Selected 86 cases of children aged 3-5 asthma, according to the children family economic conditions, factors such as adherence is divided into group A（n=42） and group B （n=44）. Group A without symptoms of asthma in children with maintenance treatment period for 1 time/d low dose （0.5 mg） atomization inhalation budesonide inhalation suspension liquid;Group B in maintenance treatment of asthma in children with asymptomatic without the need for any treatment, parents before observing children asthma symptoms occur, confirm precursors respiratory disease symptoms or performance （such as cough, stuffy nose, runny nose, tightness in the chest, etc.）, which began to give children atomization inhalation therapy, dosage regimen for intermittent high dosage regimens （respiratory disease in the early stages of the before the onset of breathing symptoms began to inhale budesonide inhalation suspension liquid, dose of 1 mg, 2 times/d, for 7 d）. Study to asthma acute oral or intravenous use of glucocorticoid therapy for the end. Observe two groups need to oral or intravenous use of glucocorticoid use acute frequency difference, acute episodes of time for the first time, 2 times of acute onset time and treatment failure rate, respiratory diseases during symptoms and symptoms of acute period. Results To reduce asthma acute attack, daily low-dose budesonide scheme is better than no intermittent high dose of budesonide scheme. Conclusion Budesonide inhalation suspension liquid 1 mg, 2 times/d intermittent, high-dose atomization inhalation therapy, continuous 7 d effectiveness when it is used in the prevention of asthma in children, curative effect and 1/d low dose （0.5 mg） no difference between the continuous suction, and intermittent high dosage regimens of budesonide exposure levels, on average, less than daily continuous inhalation.

关 键 词：儿童哮喘 持续性 间歇性 雾化吸入 布地奈德 

分 类 号：R725.6[医药卫生—儿科]