新型环糊精磁性纳米粒子的制备与包合性能研究  

Study on preparation and inclusion property of novel cyclodextrin magnetic nanoparticles

作　　者：倪明 施冬健 曾金凤 陈明清 

机构地区：[1]江南大学食品胶体与生物技术教育部重点实验室,江南大学化学与材料工程学院,无锡214122

出　　处：《化工新型材料》2015年第3期103-105,共3页New Chemical Materials

基　　金：国家自然科学基金(21004029);江苏省先进功能高分子材料设计及应用重点实验室(苏州大学)开放研究基金(KJS1141)

摘　　要：功能化的环糊精衍生物与磁性纳米粒子的复合将对药物的吸收与稳定性、用药途径和控制释放系统带来深远的影响。以无毒、可反应性的马来酸酐为原料,首先制备了环糊精接枝聚马来酸酐,再通过聚马来酸酐与Fe3O4纳米粒子间的酯化反应,制备了表面带有多个环糊精单元的磁性纳米粒子,其结构与形貌用-1H-RNMR、FT-IR、TEM等表征;重点研究所得环糊精磁性纳米粒子（CD-RPMAH MNP）对布洛芬的包合性,表明CD-RPMAH MNP对布洛芬具有较大的包合量。Complex of functional cyclodextrin （CD）derivatives and magnetic nanoparticle （MNP）may affect adsorption and stability of drugs, processing of drug in applications, and controlled release systems. CD grafted polymaleic anhydride （PMAH）was prepared using nontoxic and reactive maleic anhydride （MAH）as monomer. Novel CD magnetic nanoparticles （CD-PMAH MNP）with rich CDs on the surface of nanoparticles were prepared by esterification between PMAH and Fe3O4 nanoparticles. Structures and morphologies of CD-PMAH MNP were characterized by ^1H-NMR, FT-IR and TEM. Inclusion property of CD-PMAH MNP with Ibuprofen （IBU）was investigated in detail. The results showed that CD- PMAH MNP had great inclusion property and can absorb high amount of IBU.

关 键 词：聚马来酸酐 β-R环糊精 磁性纳米粒子 包合吸附 

分 类 号：TQ314.1[化学工程—高聚物工业] TQ460.1