雷公藤多苷联合糖皮质激素治疗免疫球蛋白A肾病的临床研究  

Clinical research of tripterygium wilfordii glycosides combined with glucocorticoid in the treatment of immunoglobulin A nephropathy

作　　者：吴凌慧[1] 叶迅[2,3] 

机构地区：[1]温州医科大学附属第六医院肾内科,浙江丽水323000 [2]浙江中医药大学附属广兴医院 [3]杭州市中医院内分泌代谢科,杭州310007

出　　处：《中国临床药理学杂志》2015年第6期418-420,共3页The Chinese Journal of Clinical Pharmacology

基　　金：浙江省中医药科技计划基金资助项目(2012EA009)

摘　　要：目的评价雷公藤多苷联合糖皮质激素治疗免疫球蛋白A(Ig A)肾病的临床疗效和安全性。方法 120例Ig A肾病患者随机分为试验组58例和对照组62例,对照组口服醋酸泼尼松片0.5 mg·kg-1,qd和氯沙坦钾50 mg·d-1,qd,试验组在对照组的基础上口服雷公藤多苷片1 mg·kg-1,tid,2组患者疗程均为3个月。观察2组的临床疗效、肾功能指标及不良反应发生率。结果试验组和对照组总有效率分别为89.7%和74.2%,试验组显著高于对照组(P<0.05);试验组治疗后尿素氮、尿酸和血肌酸酐均显著低于对照组(P<0.05),且较治疗前显著降低(P<0.05)。2组不良反发生率差异无统计学意义(P>0.05)。结论雷公藤多苷联合糖皮质激素治疗Ig A肾病较单用糖皮质激素疗效更为明显,且不增加不良反应发生率。Objective To evaluate the clinical effect and safety of tripterygium wilfordii glycosides combined with glucocorticoid in the treatment of immunoglobulin A（ Ig A） nephropathy. Methods One hundred and twenty cases with Ig A nephropathy were recruited and divided into treatment group（ n = 58） and control group（ n = 62）,and patients in control group were given prednisone acetate tablets 0. 5 mg · kg- 1and losartan potassium 50 mg·d- 1,qd. Patients in the treatment group were given tripterygium wilfordii glycosides 1 mg·kg- 1tid on the basis. After3 months treatment,the data of clinical efficacy,renal function and adverse reactions between the two groups were evaluated. Results The clinical efficacy were 89. 7% and 74. 2% in the treatment and control group,respectively,which indicated the efficacy in treatment group was higher than that in control group（ P〈 0. 05）. The data of urea nitrogen,uric acid and serum creatinine in the treatment group were significantly decrease compared with those in control group（ P〈 0. 05）. And the adverse reactions between the two groups were not statistically different（ P〈 0. 05）. Conclusion Tripterygium wilfordii glycosides combined with glucocorticoid can significantly improve the clinical symptoms of Ig A nephropathy without increasing the risk of drug related adverse reactions.

关 键 词：雷公藤多苷 糖皮质激素 免疫球蛋白A肾病 不良反应 

分 类 号：R977.1[医药卫生—药品]