重组人α-2b干扰素凝胶联合液氮冷冻治疗肛周尖锐湿疣的临床研究  

Clinical study of liquid nitrogen frozen combined with α- 2b interferon in the treatment of anal condyloma acuminatum

作　　者：韩丽林[1,2] 卢淑娇[2] 

机构地区：[1]浙江大学医学院,杭州310031 [2]丽水市人民医院皮肤科,浙江丽水323000

出　　处：《中国临床药理学杂志》2015年第6期447-449,共3页The Chinese Journal of Clinical Pharmacology

基　　金：2012年度公益性技术应用基金资助项目(2012JYZB71)

摘　　要：目的评价重组人α-2b干扰素凝胶联合液氮冷冻治疗肛周尖锐湿疣(CA)的疗效及其复发风险。方法肛周尖锐湿疣的患者155例随机分为对照组(n=84)和试验组(n=71)。对照组单独用液氮冷冻治疗,试验组用α-2b干扰素凝胶联合液氮冷冻治疗,α-2b干扰素凝胶每天4次,3个月为1疗程。观察2组患者的临床疗效及术后复发风险。结果对照组和试验组的临床总有效率分别为75.0%和95.7%,试验组显著高于对照组(P<0.05)。治疗后随访半年,试验组随访期间复发5例,对照组复发19例,试验组复发风险显著低于对照组(P<0.05)。结论液氮冷冻联合α-2b干扰素凝胶治疗肛周尖锐湿疣的临床疗效显著,且可降低术后肛周尖锐湿疣复发风险。Objective To evaluate the clinical efficacy and recurrence hazard of liquid nitrogen frozen combined with α- 2b interferon in the treatment of anal condyloma acuminatum（ CA）. Methods A total of155 cases with anal CA were included in this study and randomly divided into control group（ n = 71） and treatment group（ n = 84）. Patients in two groups were all given liquid nitrogen frozen treatment and those in treatment group were given α- 2b interferon,four times a day,3 months was a course. The data of clinical efficacy and recurrence hazard ratio（ HR）of the two groups were compared. Results The clinical efficacy were75. 0% and 95. 7% in control group and treatment group,respectively,which demonstrated that the clinical efficacy was lower in control group（ P〈 0. 05）. And the recurrence HR in treatment group was significantly lower than that in control group（ P〈 0. 05）. Conclusion The treatment of α- 2b interferon combined with liquid nitrogen frozen is effective for anal CA and can significantly decrease the recurrence rate.

关 键 词：液氮冷冻 Α-2B干扰素凝胶 肛周尖锐湿疣 

分 类 号：R541.6[医药卫生—心血管疾病]