盐酸坦洛新在输尿管镜碎石术术前的影响  

Impact of tamsulosin hydrochloride on pre-operation of ureteroscopy lithotripsy

作　　者：章卓睿[1] 张宁南[1] 邹岷[1] 肖民辉[1] 余闫宏[1] 

机构地区：[1]云南省第一人民医院泌尿外科,昆明650032

出　　处：《中国临床药理学杂志》2015年第6期472-473,477,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价盐酸坦洛新在输尿管镜碎石术术前的影响。方法 356例输尿管结石患者随机分成A、B、C组;A组126例,术前2 d口服盐酸坦洛新0.2mg;B组100例,术前2 d口服盐酸坦洛新0.4 mg;C组130例,口服维生素C 0.2mg。观察3组的输尿管镜手术时间、输尿管镜手术失败率。结果 A组手术时间为(28±12)min,输尿管镜手术失败的比例为3.17%;B组手术时间为(20±10)min,手术失败的比例为2.48%;C组手术时间为(36±14)min,输尿管镜手术失败的比例为4.62%。A,B组手术时间和手术失败率显著低于C组(P<0.05),且B组手术时间显著低于A组(P<0.05)。结论输尿管镜术前口服盐酸坦洛新,可以明显缩短手术时间、减少输尿管镜手术的失败率;且坦洛新0.4 mg效果更为明显。Objective To evaluate the impact of tamsulosin hydrochloride preoperation of ureteros-copy lithotripsy. Methods Three hundred and fifty- six cases of ureteral calculi were divided into group A,B and C. Patients in group A（ n = 126） were given tamsulosin hydrochloride0. 2 mg two days before ureteros-copy,patients in group B（ n = 100）were given tamsulosin hydrochloride 0. 4 mg two days before ureteroscopy,and patients in group C（ n = 130） only taken vitamin C 0. 2 mg.The data of ureteroscopy time and the failure rate of ureteroscopy were compared. Results The surgery times of group A,B and C were（ 28 ± 12）,（ 20 ± 10） and（ 36 ± 14） min,respectively,and proportions of surgical failure in three groups were 3. 17%,2. 48%,4. 62%,respectively,which indicated that surgery time and proportions of surgical failure in group A and B were both significantly lower than those in group C（ P〈 0. 05）,and the failure rate in group B was much lower than group A（ P〈 0. 05）. Conclusion The application of tamsulosin hydrochloride before ureteroscopy can significantly shorten the operation time,reduce the failure rate and tamsulosin 0. 4 mg is recommended.

关 键 词：输尿管镜 盐酸坦洛新 钬激光 输尿管结石 

分 类 号：R971[医药卫生—药品]