夏枯草对痤疮患者唾液中IL-1α、IL-4、IL-8和TNF-α表达的影响  

Effects of Prunella vulgaris L. on Expressions of IL- 1α,IL- 4,IL- 8 and TNF- α in Saliva of Patients with Acne

作　　者：赵俊茹[1] 汪文玉[2] 左付国[2] 李小茜[1] 胡冬裴[1] 

机构地区：[1]上海中医药大学,上海200120 [2]同济大学附属东方医院医院,上海200120

出　　处：《中国药物警戒》2015年第3期140-143,共4页Chinese Journal of Pharmacovigilance

摘　　要：目的检测夏枯草对中、重度痤疮患者唾液中白细胞介素1α(interleukin-1α,IL-1α)、白细胞介素4(interleukin-4,IL-4)、白细胞介素8(interleukin-8,IL-8)和肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)表达的影响。方法对100例中、重度痤疮患者口服夏枯草水煎液治疗,其中Ⅱ级38例,Ⅲ级27例,Ⅳ级35例,每人每日15 g,连续1周。采集非刺激性全唾液,运用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)分别检测患者治疗前后及40名正常对照者唾液中IL-1α、IL-4、IL-8和TNF-α的表达水平。结果痤疮患者唾液中IL-1α、IL-4、IL-8和TNF-α水平较对照组有不同程度的升高,其变化程度均为Ⅳ级>Ⅲ级>Ⅱ级,治疗后IL-1α、IL-4、IL-8和TNF-α水平较治疗前明显降低。结论痤疮的发病与唾液中IL-1α、IL-4、IL-8和TNF-α水平的表达密切相关,说明免疫因素是导致痤疮发生发展的重要环节,夏枯草可能通过调节痤疮患者外周免疫因素起到治疗痤疮的作用。Objective To detect effects of Prunella vulgaris L. on expressions of IL-1α、IL-4、IL-8 and TNF-α in saliva of patients with acne. Methods 100 patients with severe acne were treated with water extract of Prunella vul-garis L. for a week, 15 g·d^-1 each person, including 38Ⅱlevel patients, 27 Ⅲ level patients, 35 Ⅳ level patients. 40 cases of normal people were selected as control. The levels of IL-1α, IL-4, IL-8 and TNF-α were respectively measured before and after treatment by ELISA kits. Results Compared with the control group, the levels of IL-1α, IL-4, IL-8 and TNF-α had different degree of rise. The variability of the population were all Ⅳ level〉Ⅲ level〉Ⅱ level. The levels of IL-1α, IL-4, IL-8 and TNF-α were significantly decreased. Conclusion The onset of acne was closely related with the expression of IL-1α, IL-4, IL-8 and TNF-α in saliva, illustrating the immune factors played important roles in the onset and development of acne. Further study of the pathogenesis of acne immune mechanism has a guiding significance for clinical diagnosis and therapy, Prunella vulgaris L. may be effective for acne by adjusting peripheral immune factors in patlents with acne.

关 键 词：夏枯草 痤疮 唾液 白细胞介素 -1α 白细胞介素 -4 白细胞介素 -8 肿瘤坏死因子 -α 

分 类 号：R965[医药卫生—药理学] R282[医药卫生—药学]