基于中医症状的脑梗死后轻度认知障碍中医综合干预临床疗效评价  

Clinical efficacy evaluation of TCM comprehensive intervention on patients with mild cognitive impairment cerebral infarction based on the TCM symptoms

作　　者：李涛[1] 张昕洋 姬少珍 谢玉晗[2] 刘玥[1] 牛焕敏 陈宝鑫[2] 张丽[2] 贾蓓[1] 郝颖[1] 傅晨[2] 郭蓉娟[2] 黎明全[4] 侯小兵[5] 曹晓岚[6] 田军彪[7] 杨健[8] 张虎 张宪忠[10] 卢朋[11] 李书珍[1] 金香兰[2] 

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学东方医院,北京100078 [3]北京市第一中西医结合医院,北京100026 [4]长春中医药大学附属医院,长春130021 [5]中国中医科学院望京医院,北京100102 [6]山东中医药大学附属医院,济南250011 [7]河北医科大学中医院,石家庄050011 [8]重庆市中医院,重庆400011 [9]北京市顺义区中医院,北京101300 [10]山东省日照市中医医院,日照276800 [11]中国科学院自动化研究所,北京100190

出　　处：《北京中医药》2015年第2期103-107,共5页Beijing Journal of Traditional Chinese Medicine

基　　金：2010年中医药行业科研专项(201007002);2011年北京市科技计划(Z111107056811040);2013年首都临床特色应用研究项目(Z131107002213151)

摘　　要：目的评价中医综合干预方案对脑梗死后轻度认知障碍患者的临床疗效。方法纳入200例脑梗死后轻度认知功能障碍患者,随机分为干预组104例,对照组96例,干预组给予中药(复方苁蓉益智胶囊)+中医特色疗法+非药物干预,对照组给予非药物干预,2组疗程均180天。干预后对患者中医症状进行评价,分析患者中医症状变化情况。结果干预组"言谈不知首尾,时作时止""转盼遗忘""语后便忘,思量不能""神思不聚""言语懒""兴趣索然""烦躁易怒"等核心症状较前有所改善(P<0.01或P<0.05)。干预组"面色萎黄""口唇紫暗""头痛""失眠""目涩""口苦""神疲""乏力""心悸""身体倦重""自汗"等周边症状改善明显(P<0.01或P<0.05)。干预组"舌淡""舌有瘀斑、瘀点""苔薄"等舌脉象较治疗前改善(P<0.01或P<0.05)。结论中医综合干预方案能够有效地改善患者核心症状、周边症状及舌象,改变患者不良的主观感受,提高患者生活质量。Objective To evaluate the clinical effect of TCM comprehensive intervention on patients with the mild cognitive impairment after cerebral infarction. Methods A total of 200 patients with mild cognitive impairment after cerebral infarction were included and randomized into an intervention group（ 104 patients） and a control group（ 96 patients）. The intervention group wastreated with Chinese medicine（ Compound Congrong Yizhi Capsule） plus TCM special treatment plus non-medication intervention. The control group was treated with non-medication intervention. The treatment lasted for 180 days. The clinical symptoms were evaluated to analyze the change of TCM syndrome. Results In the intervention group,7 core symptoms of TCM were improved（ P〈0. 01 or P〈0. 05） after treatment. In the control group,11 nonsignificant symptoms of TCM were improved（ P〈0. 01 or P〈0. 05）. 3 tongue and pulse conditions were improved in the intervention group after the treatment（ P〈0. 01 or P〈0. 05）. Conclusion The TCM comprehensive intervention can effectively improve the symptoms of TCM to change the patients with poor subjective feeling and improve the daily living activities,which has good clinical efficacy.

关 键 词：脑梗死 轻度认知障碍 中医干预 中医症状 

分 类 号：R277.7[医药卫生—中医学]