色氨酸羟化酶基因A218C多态性对抑制控制影响的事件相关电位研究  

Association study on tryptophan hydroxylase gene A218C polymorphism and inhibitory control: an ERPs study

作　　者：刘永[1,2] 詹向红[2] 韩贺云[2] 王慧霞[2] 闫秀娟[2] 侯俊林[2] 王友杰[2] 

机构地区：[1]山东中医药大学基础医学院,山东济南250300 [2]河南中医学院基础医学院,河南郑州450008

出　　处：《现代中西医结合杂志》2015年第11期1141-1143,1237,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：国家自然科学基金项目(30772686;30973695)

摘　　要：目的应用事件相关电位技术,检测不同色氨酸羟化酶(TPH)基因A218C多态性被试抑制控制的脑电特征。方法以51名在校正常大学生为受试者,PCR-LDR法测定受试者基因型(AA/AC/CC),采用Go/Nogo范式,由Neuroscan系统记录并分析受试者脑电特征,比较不同基因型受试者的脑电成分。结果不同基因型受试者Go/Nogo任务的行为反应比较差异无统计学意义,不同基因型受试者N2差异波幅比较差异有统计学意义,P3波幅、N2成分波幅和潜伏期比较差异均无统计学意义。结论不同色氨酸羟化酶基因A218C多态性对大脑信息加工和处理过程产生了影响,不同基因型影响对刺激的监控过程,具有不同的脑电活动特征。Objective It is to observe the association on tryptophanhydroxylase gene A218 C polymorphism and inhibitory control by event related potentials（ERPs）.Methods 51healthy undergraduates at school were selected as subjects,behavioral data and ERPs data relevant to a visual Go / Nogo task were recorded and analyzed by Neuroscan system.The participants were assigned to 3 groups（AA / AC / CC） by their single nucleotide polymorphism type.Results No significant difference was found in either reaction time or accuracy of Nogo task among different gene type subjects（P 〉0.05）.The N2 Difference Wave（Nogo minus Go） amplitudes showed a significant difference among different gene type subjects.No significant difference was found in the P3 amplitude,N2 component amplitude,latency among different gene type subjects.Conclusion The TPH A218 C polymorphism participates in the process of cognitive control,different gene type can effect the conflict monitoring of novel stimuli with different electrical activity features.

关 键 词：色氨酸羟化酶多态性 连接酶特异检测反应 事件相关电位 执行功能 抑制控制 

分 类 号：R596[医药卫生—内科学]