超声造影监测兔肾缺血再灌注损伤早期皮质血流动力学的改变  

Contrast-enhanced ultrasonography evaluates the early changes of rabbit's cortex hemodynamics after ischemia-reperfusion injury

作　　者：叶帆[1] 李明星[1] 罗志建[1] 陈晓梅[1] 宣吉晴[1] 

机构地区：[1]泸州医学院附属医院超声诊断科,四川省646000

出　　处：《中华临床医师杂志（电子版）》2015年第6期62-65,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：四川省教育厅科研资助课题(142A0139)

摘　　要：目的采用超声造影定量分析技术监测肾缺血再灌注损伤发生后早期兔肾皮质血流灌注的改变。方法 36只家兔随机分为假手术组(R0组)、缺血后再灌注第2小时组(R1组)、第16小时组(R2组)、第24小时组(R3组),每组各9只。行超声造影并应用时间-强度曲线(TIC)测量灌注峰值时间(TTP)、曲线上升支斜率(β)、灌注峰值强度(A)、曲线下面积(AUC),观察各参数的变化并对比与兔肾病理改变的相关性。结果肾缺血恢复灌注后各组与对照组相比TTP、AUC增大,β值、A值降低(P<0.05);缺血再灌注组各组间TTP、β有统计学差异(P<0.05),其中恢复灌注后第24 h的TTP的延长和β的下降最为显著(P<0.01)。结论 肾缺血再灌注损伤早期即发生肾皮质微循环障碍,超声造影定量分析技术能敏感反映这一过程。TIC曲线各定量参数对于评价肾局部微循环灌注具有参考价值,其中TTP及β更具意义。Objective To explore the value of contrast-enhanced ultrasonography in quantitative evaluation of rabbit＇s cortex hemodynamic changes after renal ischemia-reperfusion injury in the early stage. Methods All the 36 rabbits were randomly divided into control group and different time group at 2 h, 16 h, 24 h after ischemia reperfusion. Using CEUS to observe the pattern of rabbits＇ renal perfusion and perfusion peak time（TTP）, amplitude of peak intensity（A）, curve rising slope rate（β） and area under the curve（AUC）. Discussed the relativity between quantitative evaluation of rabbit＇s cortex hemodynamics by CEUS and renal pathologic changes. Results Compared with control group, the TTP and AUC extend,β and A decreased after RIRI（P〈0.05）. TTP and β had difference in IRI groups（P〈0.05）, while the most significant changes happened at 24 h after reperfusion（P〈0.01）. Conclusion CEUS combined with quantitative analysis can catch early the rabbit＇s cortex hemodynamic changes after RIRI. CEUS can reflect this changes sensitively. Parameters analysis of time-intensity curve are effective index for evaluating rabbit renal characteristics. TTP and β seem to be more efficient.

关 键 词：肾 再灌注损伤 超声造影 定量分析 家兔 

分 类 号：R445.1[医药卫生—影像医学与核医学] R692[医药卫生—诊断学]