miRNA在糖尿病及其并发症中的作用研究进展  

Roles of miRNAs in diabetes mellitus and its complications

作　　者：杨薇[1] 韩睿[2] 

机构地区：[1]昆明医科大学研究生部,650032 [2]昆明医科大学第一附属医院糖尿病科,650032

出　　处：《中华临床医师杂志（电子版）》2015年第6期94-99,共6页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：miRNAs是在真核生物中发现的，长度大小约为20-25个核苷酸，具有调控功能的非编码的小RNA。成熟的miRNA通过碱基互补诱导了靶基因的沉默。近年来miRNAs在糖尿病中的研究，为探索糖尿病及其并发症发病机制以及早期的诊断提供了新的线索，同时也为糖尿病及其并发症的基因靶向治疗奠定了基础。本文就miRNA在糖尿病及其并发症中的作用进行综述。miRNAs are small, non-coding miRNA about 20-25 nt which were first found in eukaryon with the function of post-transcription gene expression regulation. Processing by kinds of enzymes, mature miRNAs induce target gene slience by base complementarity. Research for miRNAs involved in diabetes mellitus those years has provided new clues to explore the mechanism and early diagnosis of diabetes and its complications, meanwhile, the research has laid the foundation for target gene therapy of diabetes and its complication.

关 键 词：微RNAS 糖尿病 并发症 

分 类 号：R587[医药卫生—内分泌]