化学位移MRI对初诊2型糖尿病患者及健康人胰腺脂肪含量的比较研究  

Comparative study of pancreatic fat content between newly-diagnosed patients with type 2 diabetes and healthy volunteers by chemical shift magnetic resonance imaging

作　　者：柴军[1] 刘朋[1] 洪旭[2] 尹洁[2] 于恒池[2] 苏天昊[1] 张洁[1] 史凯宁 靳二虎[1] 

机构地区：[1]首都医科大学附属北京友谊医院放射科,北京100050 [2]首都医科大学附属北京友谊医院内分泌科,北京100050 [3]通用电气(中国)医疗集团,北京100176

出　　处：《磁共振成像》2015年第3期208-212,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：北京市自然科学基金资助项目(编号:7122048)

摘　　要：目的采用化学位移MRI研究初诊2型糖尿病患者与健康人胰腺脂肪含量的差别,探讨胰腺及肝脏脂肪含量的相关性。材料与方法搜集初诊的2型糖尿病患者70例及健康志愿者31例,分别进行化学位移同、反相位MRI检查并测量胰腺及肝脏的脂肪含量,对两组样本的胰腺脂肪含量进行比较,分析胰腺与肝脏脂肪含量的相关性。结果初诊2型糖尿病患者及健康人的胰腺脂肪含量分别为5.15%±3.75%和3.48%±1.97%(t=-3.01,P<0.05),肝脏脂肪含量分别为9.87%±3.19%和7.24%±2.38%(t=-4.56,P<0.05),两组数据差别均有统计学意义,2型糖尿病组的肝胰脂肪含量高于健康对照组;2型糖尿病组胰腺与肝脏脂肪含量的相关系数为r=0.053,健康对照组为r=0.337,两组样本的肝胰脂肪含量均不相关(P>0.05)。结论初诊2型糖尿病患者的胰腺及肝脏脂肪含量高于健康人,胰腺与肝脏的脂肪含量不相关。Objective： To compare pancreatic fat content between newly-diagnosed patients with type 2 diabetes and healthy volunteers by chemical shift MRI,and explore their correlations with hepatic fat content. Materials and Methods： Seventy patients with newly-diagnosed type 2 diabetes and BMI、gender and age matched 31 healthy volunteers were recruited in this study. Fat content in the pancreas and liver was respectively measured,calculated,and compared with the sequence of double-echo chemical shift gradient-echo magnetic resonance imaging. The correlation between liver and pancreatic fat content was analyzed. Results： The average fat content of the liver and pancreas in patients with newly-diagnosed type 2 diabetes were higher than that in the healthy volunteers. Hepatic and pancreatic fat fraction were 9.87%±3.19% and 7.24%±2.38%（t=-4.56,P〈0.05）,as well as 5.15%±3.75% and 3.48%±1.97%（t=-3.01,P〈0.05）,respectively,in the two groups,and statistically significant differences among them were obvious. Correlation coefficients in the two samples of liver and pancreatic fat content were 0.053（P〉0.05） and 0.337（P〉0.05）,both of them were not correlated each other. Conclusions： Hepatic and pancreatic fat content in newly-diagnosed patients with type 2 diabetes were higher than that of healthy volunteers,and the pancreatic and hepatic fat content were not correlated in the two groups.

关 键 词：2型糖尿病 胰腺脂肪含量 肝脏脂肪含量 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R575.5[医药卫生—诊断学]