名老中医有效经验方发现研究的探索与实践  

Exploration and Practice on Discovery Research of Effective Prescription from Prominent Traditional Chinese Medicine Doctors' Experience

作　　者：徐丽丽[1] 薛燕星[1] 张润顺[1] 周雪忠[2] 刘保延[3] 姚乃礼[3] 王映辉[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京交通大学计算机与信息技术学院,北京100044 [3]中国中医科学院,北京100700

出　　处：《中国实验方剂学杂志》2015年第7期1-4,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"十二五"科技支撑计划项目(2013BAI13B04);国家自然科学基金重点项目(81230086)

摘　　要：名老中医有效经验方是中医学术传承发展的重要载体。目前名老中医经验方的研究缺少实证,对组成、适应症的确定主观性较强。本文提出名老中医经验方必须来源于真实临床,以病例数据作为证据支撑。在阶梯递进临床疗效评价方法的理论指导下,以薛伯寿教授宣透解毒饮为例展开实践,分为有效方药初步发现、有效方药优化、有效方药验证3个步骤。有效方药优化为梯面期,以观察性研究为主;有效方药验证为竖面期,以验证性研究为主。总结提出在研究过程中需要注重病例积累,包括有效和无效病例;对计算机挖掘的数据需要进行人机结合交流;保留中医个体化辨证论治的特点,允许有效方药一定范围内的加减;提高研究质量,研究方法要符合临床研究基本要求,促进成果转化。Prominent traditional Chinese medicine （TCM） doctors＇ effective prescriptions from experience are important carriers of development and inheritance of TCM academic. Some researches of prominent TCM doctors＇ prescriptions from experience were lacking evidence. The confirmations of compositions and indications were subjective. This paper proposed that a prominent TCM experiential prescription must come from clinical practice with cases as evidence. Under the guidance that ladder-like of progressive clinical evaluation method, a preliminary practice for discover of effective prescription has made by taking Xuantou Jiedu Yin from professor XUE Bo-shou as an example. The research included three steps, like preliminary finding, optimizing and verification. Optimization of effective prescription is the tread of ladder by observation research primarily, verification of effective prescription is the vertical surface of ladder based on validation study. This paper summarized that firstly should pay attention to accumulation of clinical cases in research process, including effective and invalid cases. Secondly, data from computer mining need man-machine communication. Thirdly, characteristics of TCM individualized differentiation should be retained, addition and subtraction of herbs in effective prescription is allowed in a certain rang. Lastly, improvement of research quality and method can promote transformation of achievement.

关 键 词：名老中医 有效经验方 知识发现 经验传承 

分 类 号：R24[医药卫生—中医临床基础] R289[医药卫生—中医学]