O-季铵化-N-(4-十二烷氧基)壳聚糖苯甲醛席夫碱的制备及胶束pH响应性  

Preparation and micelle p H response of O-quaternary ammonium-N-(4-dodecyloxy) chitosan benzaldehyde Schiff's bass

作　　者：林意华[1] 李明春[1] 辛梅华[1] 陈燕燕[1] 

机构地区：[1]华侨大学材料科学与工程学院,环境友好功能材料教育部工程中心,福建厦门361021

出　　处：《化工进展》2015年第2期484-489,共6页Chemical Industry and Engineering Progress

基　　金：福建省重点科技项目(2009H0030);福建省自然科学基金(2011J01312;2012J01396);科技部科技人员服务企业项目(2009GJC40030)

摘　　要：制备双亲性的O-季铵化-N-(4-十二烷氧基)壳聚糖苯甲醛席夫碱(QA-CS-DBA),采用FTIR、1H NMR及元素分析对产物进行表征。通过超声法制备QA-CS-DBA载酮洛芬胶束,考察胶束的临界胶束浓度、粒径、Zeta电位、载药量和包封率,并对胶束在不同p H值条件下的药物释放行为及Zeta电位变化进行研究。结果表明,QA-CS-DBA能将酮洛芬包载于胶束疏水内核,载药量为39.37%,包封率为46.04%,载药胶束粒径为341nm,Zeta电位为30.8m V。胶束Zeta电位及载药胶束的药物释放行为具有p H响应性。AmphiphilicO-quaternary ammonium-N-（4-dodecyloxy） chitosan benzaldehyde Schiff’s base （QA-CS- DBA） was prepared. FTIR,1H NMR and EA were used to confirm its structure. The micelle of QA-CS-DBA carrying ketoprofen was made by ultrasounding. The CMC,size,Zeta potential,drug loading capacity and encapsulation efficiency were studied,especially the behavior of drug release and the change of Zeta potential in different PBS buffer solution with different pH. The result shows that QA-CS-DBA could form stable drug loading micelles carrying ketoprofen with the size about 341nm. The drug loading capacity and the encapsulation efficiency are 39.37% and 46.04% respectively and the Zeta potential is 30.8mV. With pH changing between 7.40 and 6.50,the micelle shows different Zeta potentials and different behaviors in drug release.

关 键 词：壳聚糖 对烷氧基苯甲醛 席夫碱 胶束 

分 类 号：O363.1[理学—流体力学]