鼠神经生长因子干预神经元特异性烯醇化酶测定阳性的宫内发育迟缓儿的疗效观察  

Observation on the curative effect of mouse nerve growth factor in intervention of intrauterine growth retardation infants with positive neuron- specific enolase

作　　者：胡冰 黄先红 张招文 黄雪松 易志刚 

机构地区：[1]江西省宜春市人民医院儿科,336000

出　　处：《中国妇幼保健》2015年第10期1541-1543,共3页Maternal and Child Health Care of China

摘　　要：目的：评价注射用鼠神经生长因子（Mouse Nerve Growth Factor for Injection,NGF）在改善神经元特异性烯醇化酶（NSE）测定阳性的宫内发育迟缓（IUGR）患儿预后中的作用。方法：选取2009年1月-2013年12月在该院出生的IUGR患儿,在新生儿娩出时立即抽取脐血,采用ELISA法测定NSE水平,将NSE水平有明显升高的86例IUGR患儿作为研究对象。按家属是否同意使用NGF分为治疗组（46例）和对照组（40例）。两组均进行早期干预及康复治疗,治疗组在此基础上加用NGF 18μg/次,每日1次肌内注射,28天为1疗程,共3个疗程;对照组不使用NGF。新生儿期第28天采用NBNA评分,1岁及2岁时评价两组干预后智力发育指数（MDI）和心理运动发育指数（PDI）。结果：治疗组患儿1岁及2岁时MDI和PDI均高于对照组,差异有统计学意义（P〈0.05）;治疗组后遗症发生率为4.3%,对照组为17.5%,两组差异有统计学意义（P〈0.05）。结论：NSE水平升高是神经损伤的敏感标志物,NGF联合早期干预可促进存在脑损伤的IUGR患儿智力发育,预防并降低神经系统后遗症。Objective： To evaluate the effect of mouse nerve growth factor （NGF） rinjeetion on improvement of intrauterine growth retardation （IUGR） infants with positive neuron - specific enolase （NSE） . Methods： IUGR infants born in the hospital from January 2009 to December 2013 were selected, umbilical blood specimens were obtained at the time of delivery, ELISA was used to detect NSE levels, 86 IUGR infants with high NSE levels significantly were selected as study objects, then they were divided into treatment group （46 infants） and control group （40 infants） according to their parents＇ desire for NGF or not. Early intervention and rehabilitation therapy were conducted in the two groups ; the infants in treatment group were treated with intramuscular injection of NGF for three courses of treatment, once a day, 18 μg per time, a course of treatment included 28 days; the infants in control group didnt receive NGF therapy. Neonatal behavioral neurological assessment （NBNA） was performed on the 28th day among these infants; mental development index （MDI） and psychomotive development index （PDI） after intervention in the two groups were compared at one and two years. Results： MDI and PDI scores in treatment group at one and two years were statistically significantly higher than those in control group （ P 〈 0. 05 ） ; the incidence rates of sequelae in intervention group and control group were 4. 3% and 17.5%, respectively, there was statistically significant difference between the two groups （ P 〈 0. 05 ） . Conclusion ： High NSE level is a sensitive marker for nerve injury, NGF combined with early intervention can promote intelligence development of IUGR infants with cerebral injury, prevent and reduce sequelae of nervous system.

关 键 词：鼠神经生长因子 神经元特异性烯醇化酶 宫内发育迟缓儿 综合干预 

分 类 号：R969.4[医药卫生—药理学]