吉林省结核分枝杆菌对利福平耐药状况分析  

Analysis of the rifampin resistance in mycobacterium tuberculosis of Jilin province

作　　者：杨修军[1] 袁燕莉[1] 张炜煜[1] 王博[1] 白云龙[1] 王艳华[1] 

机构地区：[1]吉林省卫生监测检验中心,吉林长春130062

出　　处：《中国地方病防治》2015年第1期19-20,共2页Chinese Journal of Control of Endemic Diseases

摘　　要：目的完善吉林省结核病耐药监测网络,获得国际可比性的结核病耐利福平资料,评价现行结核病控制策略的效果。方法按照WHO/IUATLD的标准,采用100%诊断中心抽样方法,对所分离培养阳性菌株进行菌型鉴定及利福平(RFP)药物敏感性测试。结果收集到可供分析的结核分枝杆菌分离株1 772株,利福平的耐药率为16.70%;其中来自初治涂阳肺结核患者的菌株为1 175株(66.14%),利福平耐药率为10.47%;来自复治涂阳肺结核患者的菌株597株(33.69%),利福平耐药率为16.70%。结论吉林省结核病利福平耐药率高于全国平均水平,今后要进一步加强耐药结核病的防治工作。Objective Surveillance network to improve drug resistance of tuberculosis of Jilin province, international comparability of TB resistant to rifampin information to evaluate the effect of the current TB control strategies. Methods According to WHO/ IUATLD standard,by using 100% of diagnostic centers sampling method, culture- positive isolates were separated bacterial type identification and rifampicin（ RFP） drug susceptibility testing. Results Collected 1 772 mycobacterium tuberculosis isolates,rifampicin resistance rate was 16. 70%; of which isolated from the early smear positive TB patients 1 175（ 66. 14%）, rifampin resistance rate was 10. 47%; isolated from retreatment smear- positive tuberculosis patients 597（ 33. 69%）, rifampicin resistance was 16. 70%. Conclusion Tuberculosis resistant to rifampin of Jilin province was higher than the national average,and need to further strengthen the prevention and treatment of drug- resistant TB.

关 键 词：肺结核 利福平 耐药 

分 类 号：R521[医药卫生—内科学]