唐山市城镇健康居民体检血清高密度脂蛋白胆固醇水平的分布  

The characteristics of serum high-density lipoprotein cholesterol levels in urban population from Tangshan City

作　　者：吴冰[1] 曲淑君 孟军华[1] 柴连海 信朝霞[1] 周云涛[1] 田卫[1] 

机构地区：[1]河北联合大学附属唐山市工人医院检验科唐山市临床分子诊断与治疗重点实验室,063000 [2]河北省遵化市人民医院检验科

出　　处：《中华检验医学杂志》2015年第2期120-123,共4页Chinese Journal of Laboratory Medicine

基　　金：河北省医学科学研究重点课题计划（ID20140121）

摘　　要：目的通过对唐山市城镇居民健康体检人群血清高密度脂蛋白胆固醇（HDL—C）水平分析，了解血清HDL—C在健康体检人群中的分布特点。方法回顾性研究。收集唐山市工人医院自2009年1月至2013年12月间36454名健康体检者临检资料，为尽量保证检测对象的健康程度，剔除了明确患病人群以及肝脏功能受损、血糖异常、肾损伤等其他人群。有效数据共计25197例，其中男性11114例，女性14083例。依据年龄划分为6组，使用匀相法检测血清HDL—C水平。数据采用R3．0．2统计学分析软件进行统计分析。采用Kolmogorov—Smimov进行正态分布检验，再采用kruskal—wallistest及Dunn muhiple comparisontest进行多组问非参数性检验。结果整体人群中血清HDL-C平均数为（1．22±0．31）mmol/L，低于1．30mmol／L的全国平均水平。血清HDL-C水平男女性别差异较大，女性血清HDL-C中位数（1．27mmol／L）水平明显高于男性（1．08mmol／L）（x^2=2606．34，P〈0．01）。男性血清HDL-C水平随年龄增长有增高的趋势，其中位数水平由1．06mmol／L升高至1．11mmol／L，且50岁以上年龄组高于50岁以下各年龄组，差异有统计学意义（x^2=75．19，P〈0．01）。依据2007年中国血脂异常防治指南，健康体检人群中29．69％（7481／25197）的个体低于1．04mmol／L，尤其在男性人群中，其异常检出率高达42．94％（4772／11114）。结论唐山市城镇地区血清HDL-C水平低于全国平均水平，且男性血清HDL—C水平随年龄呈阶梯形升高趋势。Objective To understand the characteristics of High-density lipoprotein cholesterol （HDL-C） distribution through analyzing serum HDL-C levels in healthy checkup subjects among local urbauese. Methods The checkup results of 36 454 cases were collected from 2009 to 2013 in Tangshan Gongren hospital（male： n = 20 343, female： n = 16 111 ）. The cases with liver injury, abnormal blood glucoses , kidney injury and defined cerebrovascular diseases and metabolic disease were excluded. 25 197 cases were analyzed as normal subjects including 11 114 males and 14 083 females. Kolmogorov-Smimov test, kruskal-wallis test, and Dunn multiple comparison test was performed using Bioconductor software 3.0. 2 for testing normality distribution and comparing the difference of two or multiple groups, respectively. Results were analyzed statistically with R 3.0. 2. Results The results showed that the average level （1. 22± 0. 31 ） mmol/L of HDL-C among the overall population is lower than that of national average level（ 1.30 mmo//L）. The median serum HDL-C level in female is higher than in male （1. 27 and 1.08, X^2 = 2 606. 34, P 〈0. 01 ）. HDL-C levels in male continuously increase from 1.06 mmol/L to 1.11 mmol/L with aging, especially in groups of over 50 years old than in groups of below 50 years old （X2 = 75. 19, P 〈 0. 01 ）. Conclusions Based on 2007 guidance on prevention and treatment by national health bureau, this study showed that there are 29.69% of the apparent healthy subjects, especially about 42. 94% of the male,representing low HDL-C level under the low limit of 1.04 mmol/L. These results showed that serum HDL-C level in Tangshan urbanese is lower than that of national average level, and HDL-C level in male is tended to increase with aging.

关 键 词：胆固醇 HDL 体格检查 回顾性研究 

分 类 号：R446.1[医药卫生—诊断学]