姜黄素抗肿瘤作用的研究进展  

Research progress of the antitumor effect of curcumin

作　　者：王奕智[1] 张宁[2] 

机构地区：[1]中国医科大学 [2]中国医科大学病理生理学教研室,辽宁沈阳110001

出　　处：《宝鸡文理学院学报（自然科学版）》2015年第1期41-47,共7页Journal of Baoji University of Arts and Sciences(Natural Science Edition)

基　　金：辽宁省自然科学基金(201102287);辽宁省科技厅重点课题项目(2006225001-4)

摘　　要：目的对姜黄素在肿瘤生长,增殖,转移等方面的抑制作用,即其抗肿瘤作用的研究进展进行综述,为深入进行研究和促进临床应用提供参考。方法参考国内外50余篇参考文献,对姜黄素在抗肿瘤作用方面研究进展进行概述和分析。结论应用癌细胞培养以及动物模型的方法,同时加入姜黄素作用,从调控细胞周期、诱导细胞凋亡、抑制癌细胞扩散和转移、减少炎性因子合成以及对多种肿瘤治疗手段的增效作用等方面进行了简要概述和分析研究。结论已有的研究结果表明,姜黄素能够在多方面起到抗肿瘤作用,是一种值得深入研究的抗肿瘤药物。Objective—To summarize the inhibited effect of curcumin in growth,proliferation,metastasis of tumor cells,and to provide reference for further researches and the improvement of clinical application.Methods—Through referring to more than 50 foreign and domestic reference documents,summarized and analyzed the antitumor effect of curcumin.Results—A general overview and analysis research was made in respect of regulating and controlling cell cycle,inducing cell apoptosis,inhibiting the spread and metastasis of tumor cells,decreasing the synthesis of inflammatory factors and magnifying many methods of tumor treatment by using the methods of tumor cells culture and animal model with the effect of curcumin.Conclusion—The existing researches show that curcumin has antitumor effects in different areas,and it is an antitumor medicine which is worth further research.

关 键 词：姜黄素 抗肿瘤作用 综述 

分 类 号：R979.1[医药卫生—药品] R285[医药卫生—药学]