宿主识别与应答胞质内DNA入侵的信号转导机制  

Molecular Mechanisms of Sensing and Responding to Cytosolic Microbial DNAs

作　　者：崔晔[1] 李森林[1] 王强[1] 王琛[1] 

机构地区：[1]中国科学院上海生命科学研究院生物化学与细胞生物学研究所,上海200031

出　　处：《中国细胞生物学学报》2015年第2期161-167,共7页Chinese Journal of Cell Biology

摘　　要：固有免疫是宿主防御病原微生物入侵的第一道防线。宿主通过胚系基因编码的模式识别受体(pathogen recognition receptor,PRR)监测微生物的病原相关分子模式(病毒核酸等),迅速启动免疫应答反应。宿主自身的核酸如果错误地出现在细胞质中,也会被模式识别受体识别,引发自身免疫疾病。STING(stimulator of interferon genes)是最近鉴定出的内质网接头蛋白,可以动态监控细胞内DNA以及环二核苷酸(cyclic dinucleotides,CDNs)的异常存在,发挥承上启下的抗微生物感染的枢纽功能。该文概述STING介导的细胞信号通路前沿进展,并对有待突破的科学问题作出展望。Innate immunity is the first line of host defenses against pathogens. The microbe-specific pathogen associated molecular patterns（PAMPs）, including the microbial nucleic acids, are detected by germ-line encoded pathogen recognition receptors（PRRs）, and trigger immune responses. PRRs also sense the aberrant DNAs or RNAs released by host cells, inducing autoimmune diseases. Stimulator of interferon genes（STING） has recently been uncovered as a hub signaling protein on ER, mediating the cytosolic sensing of DNAs and CDNs in innate immunity. Here, we summarize the recent advances of the STING signaling, and highlight the important issues for future investigations.

关 键 词：STING 核酸识别 细胞信号转导 固有免疫 

分 类 号：R392[医药卫生—免疫学]