Dmrt1与哺乳动物生殖细胞发育  

Dmrt1 in Mammalian Germ Cell Development

作　　者：魏于栋 申单 程慧玲[3] 李娜[2] 华进联[2] 

机构地区：[1]西北农林科技大学创新实验学院,杨凌712100 [2]西北农林科技大学动物医学院,陕西省干细胞工程技术研究中心,杨凌712100 [3]西北农林科技大学生命学院,杨凌712100

出　　处：《中国细胞生物学学报》2015年第2期278-283,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31272518);国家大学生创新计划(批准号:1310712083)资助的课题~~

摘　　要：Dmrt1是Dmrt(doublesex and mab-3 related transcription factor)基因家族成员之一,其在哺乳类、鸟类、爬行类、线虫和果蝇等多种物种中存在,是目前已知的最为保守的一个与性别分化相关的基因。该基因在性别分化期的雄性性腺及雄性成体的精巢中特异性表达,对于雄性性腺的形成和功能维持具有重要作用。该文主要简述Dmrt1在调节哺乳类动物生殖细胞发育、分化方面的研究进展及其存在的问题。Dmrt1 is a member of the Dmrt（doublesex and mab-3 related transcription factor） family, which exists in mammals, birds, reptiles, nematodes, fruit fl ies and other species. It is known as the most conservative gene that participates in the gender differentiation. It is expressed in the male gonad during gender differentiation as well as in the adult testis specifically, with a significant effect on the formation and function of male gonads. This review mainly focuses on the research and problems which exist in mammalian germ cell development and differentiation regulation by Dmrt1.

关 键 词：DMRT1 生殖细胞 性别决定 哺乳动物 

分 类 号：Q954.43[生物学—动物学]